CAJ | 학술논문

目的：研究羟丙基－β－环糊精对芦竹碱的增溶作用。方法：以芦竹碱为对照品，采用紫外分光光度法，建立芦竹碱的含量测定方法。通过相溶解度法讨论羟丙基－β－环糊精对芦竹碱的增溶作用。结果：在水溶液中，芦竹碱的溶解度随羟丙基－β－环糊精浓度的增加而呈线性增加，相溶解度曲线为AL型。结论：羟丙基－β－环糊精与芦竹碱形成1：1型包合物。羟丙基－β－环糊精对芦竹碱最大增溶倍数为4．74倍，增溶效果较好。
목적：연구간병기－β－배호정대호죽감적증용작용。방법：이호죽감위대조품，채용자외분광광도법，건립호죽감적함량측정방법。통과상용해도법토론간병기－β－배호정대호죽감적증용작용。결과：재수용액중，호죽감적용해도수간병기－β－배호정농도적증가이정선성증가，상용해도곡선위AL형。결론：간병기－β－배호정여호죽감형성1：1형포합물。간병기－β－배호정대호죽감최대증용배수위4．74배，증용효과교호。
Objective:To study the enhancing solubilization effect of hydroxypropyl -β-cyclodextrin ( HP-β-CD) with gramine using phase solubility method .Methods:An exact and precise method was developed for UV -vis absorption spectroscopy determination of gramine .Phase solubility method was used to study on the increasing solubility of HP -β-CD with Gramine .Results:The concen-tration of gramine was improved with the increase of concentration of HP -β-CD in water .The phase solubility diagram of gramine and HP-β-CD were named as AL -type.Conclusion:Gramine was included into the HP -β-CD cavum to form a 1:1 inclusion complex.The aqueous solubility of gramine -HP-β-CD was 4.74 times higher than the concentrition of gramine .The acquous solu-bility of gramine was enhanced wiht the formationg of an inclusion complex with HP -CD.