山西职工医学院学报
山西職工醫學院學報
산서직공의학원학보
JOURNAL OF SHANXI MEDICAL COLLEGE FOR CONTINUING EDUCATION
2014年
5期
12-15
,共4页
痰热清%不良反应%儿童%中药注射剂
痰熱清%不良反應%兒童%中藥註射劑
담열청%불량반응%인동%중약주사제
Tanreqing%adverse drug reactions%children%Chinese medicine injection
目的：探讨痰热清注射液致儿童不良反应的临床特点及规律，为儿童合理使用中药注射剂提供依据。方法：以“儿童”、“痰热清”、“不良反应”等为关键词，检索中国期刊全文数据库、万方数据库、维普中文期刊数据库（建库到2014年1月），进行统计分析。结果：116例药品不良反应中，以皮肤及其附件损害为主，占比47.41%。男童多于女童，1~3岁年龄组比例最高，达43.10%；不良反应发生在30 min内的占比71.55%，1 h内的占比91.38%。联合用药中以与头孢菌素类联用ADR发生率最高。结论：应重视痰热清注射液的不良反应，加强用药过程中的监测工作，采取积极有效的措施，保障儿童用药安全。
目的：探討痰熱清註射液緻兒童不良反應的臨床特點及規律，為兒童閤理使用中藥註射劑提供依據。方法：以“兒童”、“痰熱清”、“不良反應”等為關鍵詞，檢索中國期刊全文數據庫、萬方數據庫、維普中文期刊數據庫（建庫到2014年1月），進行統計分析。結果：116例藥品不良反應中，以皮膚及其附件損害為主，佔比47.41%。男童多于女童，1~3歲年齡組比例最高，達43.10%；不良反應髮生在30 min內的佔比71.55%，1 h內的佔比91.38%。聯閤用藥中以與頭孢菌素類聯用ADR髮生率最高。結論：應重視痰熱清註射液的不良反應，加彊用藥過程中的鑑測工作，採取積極有效的措施，保障兒童用藥安全。
목적：탐토담열청주사액치인동불량반응적림상특점급규률，위인동합리사용중약주사제제공의거。방법：이“인동”、“담열청”、“불량반응”등위관건사，검색중국기간전문수거고、만방수거고、유보중문기간수거고（건고도2014년1월），진행통계분석。결과：116례약품불량반응중，이피부급기부건손해위주，점비47.41%。남동다우녀동，1~3세년령조비례최고，체43.10%；불량반응발생재30 min내적점비71.55%，1 h내적점비91.38%。연합용약중이여두포균소류련용ADR발생솔최고。결론：응중시담열청주사액적불량반응，가강용약과정중적감측공작，채취적겁유효적조시，보장인동용약안전。
Objective:To investigate the general patterns and characteristics of adverse drug reactions( ADR)of Tanreqing injection to children for guiding rational drug use in the clinic. Methods:The reports involved were analyzed by retrospective study method by the aid of CNKI,Wanfang Database,VIP Chinese Periodical Database,Databasing till January 2014 as "Children","Tanreqing","adverse drug reactions",ect. as the key words downloaded for the original case reports. Results:ADR induced by Tanreqing injection could be accumulated and prompted several organ systems. Main clinical manifestations of 116 ADR cases were the disorders of skin and appendages damage which were accounting for 47. 41%. ADR appeared mostly in the age of 1 to 3(43. 10%),and more in male. 71. 55% of ADR were onset within the first 30 minutes,and almost all(91. 38%)occurred within one hour. The highest incidence rate of ADR was combination therapy with cephalosporins. Conclusion:Clinical physicians should pay attention to ADR induced by Tanreqing injection with taking the countermeasures to make medication safety.
