CAJ | 학술논문

以取代度为0、0．51、1．01的葛仙米多糖硫酸酯为原料，探讨了各样品的抗凝血活性．结果表明：葛仙米多糖硫酸酯能显著延长人活化部分凝血活酶时间（APTT）和凝血酶时间（TT），且具有一定的剂量效应关系，但对凝血酶原时间（PT）的作用不明显．说明其主要是通过抑制内源性凝血过程及共同凝血途径发挥抗凝血作用，对外源凝血途径影响较弱．
이취대도위0、0．51、1．01적갈선미다당류산지위원료，탐토료각양품적항응혈활성．결과표명：갈선미다당류산지능현저연장인활화부분응혈활매시간（APTT）화응혈매시간（TT），차구유일정적제량효응관계，단대응혈매원시간（PT）적작용불명현．설명기주요시통과억제내원성응혈과정급공동응혈도경발휘항응혈작용，대외원응혈도경영향교약．
This paper investigated the anticoagulant activity of Nostoc Sphaeroides Kützing polysaccha-ride’ s sulfuric acid ester,whose substitution degrees were 0,0.51,1.01 respectively.The results showed:Nostoc Sphaeroides Kützing polysaccharide’ s sulfuric acid ester could obviously prolong APTT and TT, and depended on the concentration but did not play a significant role to PT.So the results mainly illustra-ted that it played the function of anticlotting through inhibiting endogenous blood coagulation process and conjunct blood coagulation way,but it showed weak effect on exogenous blood coagulation way.