CAJ | 학술논문

低电压芯片电泳电色谱信号检测过程中常伴随随机、周期性激励信号干扰、基线漂移等干扰问题，为低电压芯片电泳电色谱信号的检测带来很大的困难。为了从强干扰噪声中有效提取低电压芯片电泳电色谱分离图谱，有效抑制噪声干扰，提高测量精确度及稳定性，结合低电压芯片非接触电导检测器输出信号特点，将数学形态滤波算法应用到含有强噪声干扰的芯片电泳电色谱信号去噪中。仿真结果表明：数学形态滤波能有效消除芯片电泳电色谱信号的随机、周期性激励信号干扰、基线漂移等多种噪声，能很好地保留原色谱峰信号的基本特征。由于该方法原理简单、运算速度快，易于硬件实现，适合于强背景噪声条件下的低电压芯片电泳信号实时检测。
저전압심편전영전색보신호검측과정중상반수수궤、주기성격려신호간우、기선표이등간우문제，위저전압심편전영전색보신호적검측대래흔대적곤난。위료종강간우조성중유효제취저전압심편전영전색보분리도보，유효억제조성간우，제고측량정학도급은정성，결합저전압심편비접촉전도검측기수출신호특점，장수학형태려파산법응용도함유강조성간우적심편전영전색보신호거조중。방진결과표명：수학형태려파능유효소제심편전영전색보신호적수궤、주기성격려신호간우、기선표이등다충조성，능흔호지보류원색보봉신호적기본특정。유우해방법원리간단、운산속도쾌，역우경건실현，괄합우강배경조성조건하적저전압심편전영신호실시검측。
During the electro-chromatography detection process of low-voltage capillary electrophoresis micro-chip,the signals are frequently affected by strong noise interference, such as the random disturb-ance,periodic excitation signal interference, baseline drift, and so on, which brought about great difficul-ties for the electro-chromatography signal analysis.In order to effectively extract the electro-chromatogra-phy graph of low-voltage capillary electrophoresis micro-chip, effectively restrain the noise interference and enhance the measurement precision and stability, the denoising algorithm based on mathematical morphology filter, which is applied in processing the electro-chromatography signal of low-voltage capil-lary electrophoresis micro-chip with strong noise interference, was presented.The simulation results show that the mathematical morphology filter can effectively eliminate the random disturbance,periodic excita-tion signal interference, baseline drift, etc, and can retain the basic characteristics of original chromato-graphic peak signal.Due to the advantages of simple principle and fast operation speed, easy to imple-ment by hardware,it is suitable for the real-time signal detection of low-voltage capillary electrophoresis micro-chip with strong background noise.