CAJ | 학술논문

目的：探讨2型尿病和以及不同并发症患者血清护骨素（ OPG）水平及调脂治疗前后其水平的比较。方法：新诊断的2型糖尿病以及合并神经病变、视网膜病变和冠心病患者各50例，另选年龄性别相匹配的50例健康者为对照组，采用ELISA法检测不同组血清OPG水平；比较辛伐他汀治疗2周后护骨素水平的变化。结果：血清同型半胱氨酸和护骨素水平在2型糖尿病及不同并发症组明显高于对照组，而且DM-CVD组与DM组之间存在显著差异。调脂治疗2周后护骨素水平比较无显著差异。结论：血清护骨素在新发2型糖尿病组以及合并神经、视网膜和冠心病组患者中明显升高，与血糖控制指标相关。
목적：탐토2형뇨병화이급불동병발증환자혈청호골소（ OPG）수평급조지치료전후기수평적비교。방법：신진단적2형당뇨병이급합병신경병변、시망막병변화관심병환자각50례，령선년령성별상필배적50례건강자위대조조，채용ELISA법검측불동조혈청OPG수평；비교신벌타정치료2주후호골소수평적변화。결과：혈청동형반광안산화호골소수평재2형당뇨병급불동병발증조명현고우대조조，이차DM-CVD조여DM조지간존재현저차이。조지치료2주후호골소수평비교무현저차이。결론：혈청호골소재신발2형당뇨병조이급합병신경、시망막화관심병조환자중명현승고，여혈당공제지표상관。
Objective To explore the levels of serum osteoprotegerin in type 2 diabetes and with different complicationsandtheeffectoflipid-loweringtherapy.Methods 50casesofNewly-diagnosedtype2diabetesand diabetic neuropathy , retinopathy and coronary heart disease , 50 healthy people in gender and age matched control group, ELISA method was used to detect the level of serum OPG in different groups;Changes in levels of OPG after 2 weeks of simvastatin treatment .Results The serum homocysteine and osteoprotegerin levels in type 2 diabetes mellitus and different complications groups were significantly higher than that in control group , and there was signif-icant difference between group DMCVD and group DM .Serum osteoprotegerin levels showed no significant differ-ence after 2 weeks of Lipid-lowering therapy .Conclusion Serum osteoprotegerin in Newly-diagnosed type 2 diabe-tes and diabetic neuropathy , retinopathy and coronary heart disease groups were significantly increased and associ -ated with glycemic control index .