中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
2期
214-217
,共4页
赵向前%梁斌%张安红%黄晓强
趙嚮前%樑斌%張安紅%黃曉彊
조향전%량빈%장안홍%황효강
Ki-67抗原%DNA拓扑异构酶类,Ⅱ型%预后%壶腹癌
Ki-67抗原%DNA拓撲異構酶類,Ⅱ型%預後%壺腹癌
Ki-67항원%DNA탁복이구매류,Ⅱ형%예후%호복암
Ki-67 antigen%DNA topoisomerases,typeⅡ%Prognosis%Ampullary carcinoma
目的:研究Ki-67、DNA拓扑异构酶Ⅱα(TopoⅡα)在壶腹癌中的表达,探讨其与壶腹癌病理及生存状况的关系。方法应用 SP 免疫组化技术,检测71例壶腹癌 Ki-67、TopoⅡα的表达,并对其与壶腹癌病理及预后的关系进行分析。结果 Ki-67、TopoⅡα的阳性表达率分别为71.8%(51/71),45.1%(32/71);Ki-67、TopoⅡα的表达以及两者的共表达均与肿瘤直径有关(P=0.008,P=0.029,P=0.004)。Ki-67与TopoⅡα的表达呈显著正相关(r=0.378,P=0.001)。Ki-67、TopoⅡα阴性表达者的术后生存率明显优于阳性表达者(P=0.018,P=0.001)。Ki-67与TopoⅡα共阳性表达者的生存率明显低于共阴性表达或单阴性表达者(P=0.001,P=0.018)。结论 Ki-67、Top oⅡα可作为判断壶腹癌患者预后的参考指标,联合检测二者的表达水平对壶腹癌的预后判断有一定的参考意义。
目的:研究Ki-67、DNA拓撲異構酶Ⅱα(TopoⅡα)在壺腹癌中的錶達,探討其與壺腹癌病理及生存狀況的關繫。方法應用 SP 免疫組化技術,檢測71例壺腹癌 Ki-67、TopoⅡα的錶達,併對其與壺腹癌病理及預後的關繫進行分析。結果 Ki-67、TopoⅡα的暘性錶達率分彆為71.8%(51/71),45.1%(32/71);Ki-67、TopoⅡα的錶達以及兩者的共錶達均與腫瘤直徑有關(P=0.008,P=0.029,P=0.004)。Ki-67與TopoⅡα的錶達呈顯著正相關(r=0.378,P=0.001)。Ki-67、TopoⅡα陰性錶達者的術後生存率明顯優于暘性錶達者(P=0.018,P=0.001)。Ki-67與TopoⅡα共暘性錶達者的生存率明顯低于共陰性錶達或單陰性錶達者(P=0.001,P=0.018)。結論 Ki-67、Top oⅡα可作為判斷壺腹癌患者預後的參攷指標,聯閤檢測二者的錶達水平對壺腹癌的預後判斷有一定的參攷意義。
목적:연구Ki-67、DNA탁복이구매Ⅱα(TopoⅡα)재호복암중적표체,탐토기여호복암병리급생존상황적관계。방법응용 SP 면역조화기술,검측71례호복암 Ki-67、TopoⅡα적표체,병대기여호복암병리급예후적관계진행분석。결과 Ki-67、TopoⅡα적양성표체솔분별위71.8%(51/71),45.1%(32/71);Ki-67、TopoⅡα적표체이급량자적공표체균여종류직경유관(P=0.008,P=0.029,P=0.004)。Ki-67여TopoⅡα적표체정현저정상관(r=0.378,P=0.001)。Ki-67、TopoⅡα음성표체자적술후생존솔명현우우양성표체자(P=0.018,P=0.001)。Ki-67여TopoⅡα공양성표체자적생존솔명현저우공음성표체혹단음성표체자(P=0.001,P=0.018)。결론 Ki-67、Top oⅡα가작위판단호복암환자예후적삼고지표,연합검측이자적표체수평대호복암적예후판단유일정적삼고의의。
Objective To examine the expression of Ki-67 and topoisomeraseⅡα( TopoⅡα) in ampullary carcinoma, and investigate the correlation of Ki-67, TopoⅡα with pathological data and prognosis. Methods The SP immunohistochemical method was used to examine the expression of Ki-67, TopoⅡα in 71 ampullary carcinomas. The correlation of the two factors with pathological data and prognosis was analyzed statistically. Results The positive rate of Ki-67 and TopoⅡα expression was 71.8%(51/71), 45.1%(31/71), respectively. The expression of Ki-67, TopoⅡαand their coexpression were associated with tumor diameter (P=0.008, P=0.029, P=0.004). Ki-67 expression was significantly correlated with TopoⅡαexpression (r=0.378, P=0.001).The expression of Ki-67, TopoⅡαhad significant negative correlation with survival period (P=0.018, P=0.001). The survival period of patients with coexpression of Ki-67 and TopoⅡα was obviously lower than those without Ki-67 and/or TopoⅡαexpression (P=0.001, P=0.018). Conclusion Ki-67 and TopoⅡα are important prognosis factors for ampullary carcinoma patients. Combined detection of Ki-67 and TopoⅡαmay play a more important role in prognostic prediction of ampullary carcinoma.