CAJ | 학술논문

增生性瘢痕的发生发展与烧（创）伤患者密切相关，其防治一直是创伤康复领域的研究重点和难点。花生四烯酸作为人体内性质活跃的必需脂肪酸之一，广泛参与炎症反应、氧化应激以及发挥第二信使作用等，其在防治瘢痕增生过程中可能具有重要作用。本文就花生四烯酸生物学作用的研究和增生性瘢痕发生机制，以及花生四烯酸与增生性瘢痕关系的研究进行综述。
증생성반흔적발생발전여소（창）상환자밀절상관，기방치일직시창상강복영역적연구중점화난점。화생사희산작위인체내성질활약적필수지방산지일，엄범삼여염증반응、양화응격이급발휘제이신사작용등，기재방치반흔증생과정중가능구유중요작용。본문취화생사희산생물학작용적연구화증생성반흔발생궤제，이급화생사희산여증생성반흔관계적연구진행종술。
The formation and development of hypertrophic scar are closely related with the burn (trauma) patients, its prevention and treatment has been a research focus and difficulty in the field of trauma rehabilitation. Arachidonic acid is one of the essential fatty acids in vivo which widely participates in inflammation, oxidative stress and plays a second messenger role, so it may play an important role in the process of prevention and treatment of hypertrophic scar. This paper mainly reviewed the current research status of arachidonic acid in hypertrophic scar.