CAJ | 학술논문

目的：对难治性肾病综合征采用不同治疗方案进行治疗，比较其临床疗效。方法将44例难治性肾病综合征患者随机均分成实验组和对照组（n=22）。对照组患者给予盐酸氮芥进行治疗，实验组患者给予环磷酰胺进行治疗。比较2组患者的临床疗效及血清IL-2、IL-6及TNF-a水平。结果经过治疗后，实验组患者的总有效率（90.91%）显著高于对照组患者的总有效率（63.64%），差异有统计学意义（P<0.05）；2组患者的血清IL-2、IL-6及TNF-a水平均有显著差异（P<0.05）。结论对难治性肾病综合征的患者采用环磷酰胺治疗的临床效果较好，安全可靠，在临床上值得广泛运用。
목적：대난치성신병종합정채용불동치료방안진행치료，비교기림상료효。방법장44례난치성신병종합정환자수궤균분성실험조화대조조（n=22）。대조조환자급여염산담개진행치료，실험조환자급여배린선알진행치료。비교2조환자적림상료효급혈청IL-2、IL-6급TNF-a수평。결과경과치료후，실험조환자적총유효솔（90.91%）현저고우대조조환자적총유효솔（63.64%），차이유통계학의의（P<0.05）；2조환자적혈청IL-2、IL-6급TNF-a수평균유현저차이（P<0.05）。결론대난치성신병종합정적환자채용배린선알치료적림상효과교호，안전가고，재림상상치득엄범운용。
Objective To analyze clinical efifcacy of different treatments in curing refractory nephrotic syndrome.Methods From Jan 2013 to Jan 2014, 44 patients with refractory nephrotic syndrome who received treatment in Ganzhou City People's Hospital were divided into experimental group and control group equally(n=22). Control group patients were treated with chlormethine hydrochloride while experimental group were treated with cyclophosphamide. Compare their clinical effect and serum IL-2, IL-6 and TNF-a levels after treatment.Results After treatment, the total effective rate in experimental group (90.91%) was higher than the control group (63.64%), and the difference was statistically signiifcant (P<0.05);And the serum IL-2,IL-6 and TNF-a levels of two groups were signiifcantly different, and the the difference was statistically signiifcant(P<0.05). Conclusion Cyclophosphamide has better curative effect in treating refractory nephrotic syndrome with safety and reliability, so it is worthy of wide clinical use.