CAJ | 학술논문

目的：探讨血尿酸（UA）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、脂蛋白（LPL）、高敏 C 反应蛋白（hs-CRP）水平与2型糖尿病合并痛风的相关性。方法对2型糖尿病合并痛风组、2型糖尿病无痛风组和痛风组的 UA、TC、TG、HDL-C、LDL-C、LPL、hs-CRP 值进行测定，统计分析3组间各生化指标的差异是否有统计学意义。结果与2型糖尿病无痛风组相比，2型糖尿病合并痛风组 TG、LDL-C、hs-CRP、UA 水平均升高（P ＜0．05）， HDL-C 水平降低（P ＜0．05）；与痛风组相比，2型糖尿病合并痛风组 GLU、TG、LDL-C、LPL、hs-CRP、UA 水平均升高（P ＜0．05）， HDL-C 水平降低（P ＜0．05）。2型糖尿病合并痛风组 UA 与 GLU、TC、TG、LDL-C、LPL、hs-CRP 呈正相关（P ＜0．05），相关系数分别为0．313、0．283、0．422、0．297、0．436；与 HDL-C 呈负相关（P ＜0．05），相关系数为－0．523。结论 UA、TC、TG、HDL-C、LDL-C、LPL、hs-CRP 指标与2型糖尿病合并痛风密切相关，对这些生化指标的检测有助于监测和控制2型糖尿病合并痛风的发生和发展。
목적：탐토혈뇨산（UA）、총담고순（TC）、삼선감유（TG）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）、지단백（LPL）、고민 C 반응단백（hs-CRP）수평여2형당뇨병합병통풍적상관성。방법대2형당뇨병합병통풍조、2형당뇨병무통풍조화통풍조적 UA、TC、TG、HDL-C、LDL-C、LPL、hs-CRP 치진행측정，통계분석3조간각생화지표적차이시부유통계학의의。결과여2형당뇨병무통풍조상비，2형당뇨병합병통풍조 TG、LDL-C、hs-CRP、UA 수평균승고（P ＜0．05）， HDL-C 수평강저（P ＜0．05）；여통풍조상비，2형당뇨병합병통풍조 GLU、TG、LDL-C、LPL、hs-CRP、UA 수평균승고（P ＜0．05）， HDL-C 수평강저（P ＜0．05）。2형당뇨병합병통풍조 UA 여 GLU、TC、TG、LDL-C、LPL、hs-CRP 정정상관（P ＜0．05），상관계수분별위0．313、0．283、0．422、0．297、0．436；여 HDL-C 정부상관（P ＜0．05），상관계수위－0．523。결론 UA、TC、TG、HDL-C、LDL-C、LPL、hs-CRP 지표여2형당뇨병합병통풍밀절상관，대저사생화지표적검측유조우감측화공제2형당뇨병합병통풍적발생화발전。
Objective To explore the correlation between the levels of uric acid(UA),plasma total cholesterol(TC),triglyceride (TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol (LDL-C),lipoprotein A(LPL)and hyper-sensitive C-reactive protein(hs-CRP)with type 2 diabetes mellitus(T2DM)complicating gout.Methods The levels of UA,TC, TG,HDL-C,LDL-C,LPL and hs-CRP in the T2DM complicating gout group,the T2DM without gout group and the gout group were measured and statistically analyzed to evaluate whether the differences of these indicators among 3 groups having statistical significance.Results Compared with the T2DM without gout group,the TG,LDL-C,hs-CRP and UA levels in the T2DM compli-cating gout were increased (P <0.05),while the HDL-C level was decreased(P <0.05).Ccompared with the gout group,the GLU, TG,LDL-C,LPL,hs-CRP and UA levels in the T2DM complicating gout group were significantly increased (P <0.05 )and the HDL-C level was decreased(P <0.05).The UA level in the T2DM complicating gout group was positively correlated with GLU, TC,TG,LDL-C,LPL and hs-CRP levels(P <0.05),the correlation coefficient were 0.313,0.283,0.422,0.297 and 0.436 respec-tively,which was negatively correlated with HDL-C(P <0.05),the correlation coefficient was -0.523.Conclusion The UA,TC, TG,HDL-C,LDL-C,LPL and hs-CRP levels have close correlation with T2DM complicating gout,detecting these biochemical indi-cators is helpful to monitor and control the occurrence and the development of T2DM complicating gout.