国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
1期
80-81,84
,共3页
周红荣%胡荷宇%李海川%王忠英%龚波
週紅榮%鬍荷宇%李海川%王忠英%龔波
주홍영%호하우%리해천%왕충영%공파
非典型腺细胞%人乳头瘤病毒亚型%液基细胞涂片
非典型腺細胞%人乳頭瘤病毒亞型%液基細胞塗片
비전형선세포%인유두류병독아형%액기세포도편
atypical glandular cell%HPV subtypes%LBP
目的:根据人乳头瘤病毒(HPV)感染亚型和组织学病理结果探讨非典型腺细胞(AGC)的临床结局。方法收集2009年1月1日至2014年2月28日在上海市长宁区妇幼保健院妇科门诊检查及治疗的102例 AGC 患者的宫颈液基细胞学(LBP)、HPV 和组织学资料,进行临床结果分析。结果67218名接受 LBP 检查患者中,AGC 患者102例,发病率为0.15%。AGC 无特异性(NOS)患者中,正常或良性病变67例,癌前和恶性病变11例;AGC 倾向于肿瘤患者中,良性病变、癌前和恶性病变分别为7例、14例和3例。同时,AGC-NOS 患者中,HPV 感染64例,其中高危型感染57例(16、52、45型),低危型感染7例(6、11型),单项感染、双重感染、三重感染分别为54、6、4例;AGC 倾向于肿瘤的患者中,HPV 感染19例,其中高危型感染18例(52、16、18型),低危型感染1例(6型),单项感染、双重感染分别为15、4例。结论 AGC 对宫颈恶性病变的预测起到了重要作用,不同 HPV 亚型感染在 AGC 相关肿瘤中的结果对宫颈不良病变的预测也发挥了一定作用,两者结合分析是判断妇科宫颈癌前病变和恶性肿瘤发生的重要信号,即 AGC 结合相应的 HPV 感染亚型,不仅为宫颈病变作出判断,也对妇科恶性肿瘤高风险存在的预测提供依据,对中国区域性宫颈癌的疫苗制造与推广提供建设性意见。
目的:根據人乳頭瘤病毒(HPV)感染亞型和組織學病理結果探討非典型腺細胞(AGC)的臨床結跼。方法收集2009年1月1日至2014年2月28日在上海市長寧區婦幼保健院婦科門診檢查及治療的102例 AGC 患者的宮頸液基細胞學(LBP)、HPV 和組織學資料,進行臨床結果分析。結果67218名接受 LBP 檢查患者中,AGC 患者102例,髮病率為0.15%。AGC 無特異性(NOS)患者中,正常或良性病變67例,癌前和噁性病變11例;AGC 傾嚮于腫瘤患者中,良性病變、癌前和噁性病變分彆為7例、14例和3例。同時,AGC-NOS 患者中,HPV 感染64例,其中高危型感染57例(16、52、45型),低危型感染7例(6、11型),單項感染、雙重感染、三重感染分彆為54、6、4例;AGC 傾嚮于腫瘤的患者中,HPV 感染19例,其中高危型感染18例(52、16、18型),低危型感染1例(6型),單項感染、雙重感染分彆為15、4例。結論 AGC 對宮頸噁性病變的預測起到瞭重要作用,不同 HPV 亞型感染在 AGC 相關腫瘤中的結果對宮頸不良病變的預測也髮揮瞭一定作用,兩者結閤分析是判斷婦科宮頸癌前病變和噁性腫瘤髮生的重要信號,即 AGC 結閤相應的 HPV 感染亞型,不僅為宮頸病變作齣判斷,也對婦科噁性腫瘤高風險存在的預測提供依據,對中國區域性宮頸癌的疫苗製造與推廣提供建設性意見。
목적:근거인유두류병독(HPV)감염아형화조직학병리결과탐토비전형선세포(AGC)적림상결국。방법수집2009년1월1일지2014년2월28일재상해시장저구부유보건원부과문진검사급치료적102례 AGC 환자적궁경액기세포학(LBP)、HPV 화조직학자료,진행림상결과분석。결과67218명접수 LBP 검사환자중,AGC 환자102례,발병솔위0.15%。AGC 무특이성(NOS)환자중,정상혹량성병변67례,암전화악성병변11례;AGC 경향우종류환자중,량성병변、암전화악성병변분별위7례、14례화3례。동시,AGC-NOS 환자중,HPV 감염64례,기중고위형감염57례(16、52、45형),저위형감염7례(6、11형),단항감염、쌍중감염、삼중감염분별위54、6、4례;AGC 경향우종류적환자중,HPV 감염19례,기중고위형감염18례(52、16、18형),저위형감염1례(6형),단항감염、쌍중감염분별위15、4례。결론 AGC 대궁경악성병변적예측기도료중요작용,불동 HPV 아형감염재 AGC 상관종류중적결과대궁경불량병변적예측야발휘료일정작용,량자결합분석시판단부과궁경암전병변화악성종류발생적중요신호,즉 AGC 결합상응적 HPV 감염아형,불부위궁경병변작출판단,야대부과악성종류고풍험존재적예측제공의거,대중국구역성궁경암적역묘제조여추엄제공건설성의견。
Objective To research the clinical outcome of atypical glandular cell (AGC)according to various subtypes of HPV infection and histological pathology results.Methods The data of the liquid-bases cytology (LBP),HPV infection and histology in 102 cases of AGC at the gynecology outpatient department of our hospital from January 1 ,2009 to February 28,2014 were collected and performed the analysis on their clinical outcomes.Results Among 67 218 cases of LBP detection,102 cases were AGC with the total incidence rate of 0.15%.In the cases of AGC-NOS,67 cases were normal or benign lesions,11 cases were precancerous lesion and malignant lesions;in the cases of AGC treading to tumor,the benign,precancerous and malignant lesions were in 7,14 and 3 ca-ses respectively.At the same time in the cases of AGC-NOS,HPV infection was in 64 cases,in which 57 cases were high risk infec-tion(type 16,52,45)and 7 cases were low risk infection(type 6,11 ).The single infection,double infection and multiple infection were in 54,6 cases respectively;in the cases of AGC trends to neoplasm,HPV infection was in 19 cases,in which 18 cases were high risk infection(type 52,16,18)and 1 case was low risk infection(type 6),single infection and double infection were in 15 cases and 4 cases respectively.Conclusion AGC may play an important role for the forecast of cervical malignant lesions.The results of differ-ent HPV subtypes infection in AGC related tumors also play a certain role in the prediction of cervical neoplasia.Their combined a-nalysis is the important signal for judging the occurrence of gynecological cervical precancerous lesion and malignant tumor,i.e., AGC combining with the corresponding HPV subtype infection not only can make a judgement for the cervical lesions,but also pro-vides the basis for predicting the high risk existence of gynecological malignant tumor and provides constructive suggestions for Chi-na regional cervical carcinoma vaccine manufacturing and promotion.