CAJ | 학술논문

目的：应用扩散张量成像（diffusion tensor imaging，DTI）技术评价常规 MRI平扫正常的发育迟缓儿童脑白质损伤。方法选取12～36个月常规 MRI平扫正常的20例发育迟缓儿童及20例同龄发育正常对照组儿童进行常规MRI平扫及DTI检查。分别测量4个浅部脑白质与5个深部脑白质感兴趣区（region of interest，ROI）的各向异性（fractional anisotropy，FA）值及平均扩散率（mean diffusivity，MD）值。结果发育迟缓组浅部脑白质FA值明显低于对照组（P＜0．05），发育迟缓组浅部脑白质及深部脑白质胼胝体压部 MD值高于正常对照组（P＜0．05）；发育迟缓组深部脑白质 FA值与对照组比较差异无统计学意义。结论应用扩散张量成像 FA值及 MD值能早期定量诊断常规 MR平扫正常的儿童脑白质发育迟缓。
목적：응용확산장량성상（diffusion tensor imaging，DTI）기술평개상규 MRI평소정상적발육지완인동뇌백질손상。방법선취12～36개월상규 MRI평소정상적20례발육지완인동급20례동령발육정상대조조인동진행상규MRI평소급DTI검사。분별측량4개천부뇌백질여5개심부뇌백질감흥취구（region of interest，ROI）적각향이성（fractional anisotropy，FA）치급평균확산솔（mean diffusivity，MD）치。결과발육지완조천부뇌백질FA치명현저우대조조（P＜0．05），발육지완조천부뇌백질급심부뇌백질변지체압부 MD치고우정상대조조（P＜0．05）；발육지완조심부뇌백질 FA치여대조조비교차이무통계학의의。결론응용확산장량성상 FA치급 MD치능조기정량진단상규 MR평소정상적인동뇌백질발육지완。
Objective To observe the changes of white matter by using diffusion tensor imaging(DTI ) in developmental delay children with normal routine MRI results.Methods Twenty patients (aged 1 2-3 6 months)with developmental delay and the twenty cases of month-old matched normal development children were studied by conventional MRI and DTI technology. Fractional anisotropy(FA)and mean diffusivity(MD)values were measured in five regions of deep white matter and four regions of shallow white matter.Comparison were made in FA and MD values of developmental normal and development delay children.Results FA value in shallow white matter of developmental delay children was lower than that of control group (P<0.05), MD values in shallow white matter and corpus callosum knee of developmental delay children was higher than that of control group (P<0.05).Conclusion DTI may quantify the injuries of white matter microstructure in developmental delay children with normal routine MRI results.