国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
1期
17-19
,共3页
叶青跃%杨扬%杜丹心%程鹏飞%张明洁
葉青躍%楊颺%杜丹心%程鵬飛%張明潔
협청약%양양%두단심%정붕비%장명길
糖尿病足%甲钴胺%灯盏花注射液
糖尿病足%甲鈷胺%燈盞花註射液
당뇨병족%갑고알%등잔화주사액
diabetic foot%mecobalamin%breviscapin injection
目的:观察大剂量甲钴胺联合灯盏花注射液对糖尿病足(DF)患者血清肿瘤坏死因子-α(TNF-α)、C 反应蛋白(CRP)水平及抗凝血酶Ⅲ(AT-Ⅲ)活性的影响。方法240例 DF 患者按随机数字表法分为4组:大剂量甲钴胺+灯盏花注射液治疗组60例(Ⅳ组),常规剂量甲钴胺+灯盏花注射液治疗组60例(Ⅲ组),单纯灯盏花注射液治疗组60例(Ⅱ组),单纯常规剂量甲钴胺治疗组60例(Ⅰ组),4周为1疗程。治疗前后检测 TNF-α、CRP 水平及 AT-Ⅲ活性并进行对比分析。结果治疗前4组血清TNF-α、CRP 及 AT-Ⅲ检测结果之间差异无统计学意义(P >0.05);分别行治疗前后比较,4组治疗后血清 TNF-α及 CRP 结果均较治疗前降低,AT-Ⅲ水平升高,差异有统计学意义(P <0.05);Ⅳ组与Ⅰ、Ⅱ、Ⅲ组治疗后比较,差异有统计学意义(P <0.05)。结论甲钴胺联合灯盏花注射液能降低 DF 患者血清中炎性因子如 TNF-α及 CRP 的水平,并使 AT-Ⅲ活性升高,尤其是甲钴胺浓度增加时效果更显著。因此,采取增加甲钴胺浓度联合灯盏花注射液的治疗方法能更明显地降低 DF 的炎症反应,且安全性好,是提高治疗 DF 的有效手段之一。
目的:觀察大劑量甲鈷胺聯閤燈盞花註射液對糖尿病足(DF)患者血清腫瘤壞死因子-α(TNF-α)、C 反應蛋白(CRP)水平及抗凝血酶Ⅲ(AT-Ⅲ)活性的影響。方法240例 DF 患者按隨機數字錶法分為4組:大劑量甲鈷胺+燈盞花註射液治療組60例(Ⅳ組),常規劑量甲鈷胺+燈盞花註射液治療組60例(Ⅲ組),單純燈盞花註射液治療組60例(Ⅱ組),單純常規劑量甲鈷胺治療組60例(Ⅰ組),4週為1療程。治療前後檢測 TNF-α、CRP 水平及 AT-Ⅲ活性併進行對比分析。結果治療前4組血清TNF-α、CRP 及 AT-Ⅲ檢測結果之間差異無統計學意義(P >0.05);分彆行治療前後比較,4組治療後血清 TNF-α及 CRP 結果均較治療前降低,AT-Ⅲ水平升高,差異有統計學意義(P <0.05);Ⅳ組與Ⅰ、Ⅱ、Ⅲ組治療後比較,差異有統計學意義(P <0.05)。結論甲鈷胺聯閤燈盞花註射液能降低 DF 患者血清中炎性因子如 TNF-α及 CRP 的水平,併使 AT-Ⅲ活性升高,尤其是甲鈷胺濃度增加時效果更顯著。因此,採取增加甲鈷胺濃度聯閤燈盞花註射液的治療方法能更明顯地降低 DF 的炎癥反應,且安全性好,是提高治療 DF 的有效手段之一。
목적:관찰대제량갑고알연합등잔화주사액대당뇨병족(DF)환자혈청종류배사인자-α(TNF-α)、C 반응단백(CRP)수평급항응혈매Ⅲ(AT-Ⅲ)활성적영향。방법240례 DF 환자안수궤수자표법분위4조:대제량갑고알+등잔화주사액치료조60례(Ⅳ조),상규제량갑고알+등잔화주사액치료조60례(Ⅲ조),단순등잔화주사액치료조60례(Ⅱ조),단순상규제량갑고알치료조60례(Ⅰ조),4주위1료정。치료전후검측 TNF-α、CRP 수평급 AT-Ⅲ활성병진행대비분석。결과치료전4조혈청TNF-α、CRP 급 AT-Ⅲ검측결과지간차이무통계학의의(P >0.05);분별행치료전후비교,4조치료후혈청 TNF-α급 CRP 결과균교치료전강저,AT-Ⅲ수평승고,차이유통계학의의(P <0.05);Ⅳ조여Ⅰ、Ⅱ、Ⅲ조치료후비교,차이유통계학의의(P <0.05)。결론갑고알연합등잔화주사액능강저 DF 환자혈청중염성인자여 TNF-α급 CRP 적수평,병사 AT-Ⅲ활성승고,우기시갑고알농도증가시효과경현저。인차,채취증가갑고알농도연합등잔화주사액적치료방법능경명현지강저 DF 적염증반응,차안전성호,시제고치료 DF 적유효수단지일。
Objective To observe the influence of large dose of mecobalamin combining with breviscapin injection on the levels of serum tumor necrosis factor-α(TNF-α)and C-reactive protein (CRP)and the antithrombin Ⅲ(AT-Ⅲ)activity in the patients with diabetic foot(DF).Methods 240 cases of DF were divided into 4 groups according to the random number table method,60 cases in each group:the large dose of mecobalamin plus breviscapin injection group (group Ⅳ);the routine dose of mecobalamin plus brevis-capin injection group (group Ⅲ);the simple breviscapin injection group (group Ⅱ)and the routine dose of mecobalamin group (groupⅠ).4 weeks were taken as a course of treatment.The TNF-α,CRP levels and the AT-Ⅲ activity before and after the treat-ment were detected and performed the comparative analysis.Results The levels of TNF-α,CRP and AT-Ⅲ before treatment had no statistically significant differences among in the four groups (P >0.05).Compared with the results before treatment,the levels of TNF-αand CRP after treatment in 4 groups were obviously decreased and the AT-Ⅲ level was significantly increased,the differ-ences had statistical significance (P <0.05);compared with the group Ⅰ,Ⅱ and Ⅲ,the difference in the group Ⅳ had statistical significance(P <0.05).Conclusion Mecobalamin combined with breviscapin injection is able to decrease the serum inflammatory factors such as TNF-αand CRP,and increase the AT-Ⅲ activity in the patients with DF,which is more significant when increasing the mecobalamin concentration.Therefore,adopting the therapeutical scheme of increasing the mecobalamin concentration combined with breviscapin injection could obviously decrease the inflammatory reaction of DF with good safety,which is one of effective meas-ures for increasing the curative effect of DF.