CAJ | 학술논문

目的：通过对广州地区复发性自然流产（RSA）夫妇进行染色体核型分析，探讨 RSA 与染色体异常的关系。方法对广州地区394对 RSA 夫妇外周血做淋巴细胞培养并进行染色体核型分析。结果394对 RSA 夫妇中，染色体异常41例，异常率为5．2％，其中染色体数目异常1例（2．44％），平衡易位8例（19．51％），罗伯逊易位3例（7．32％），染色体倒位1例（2．44％），染色体多态变异28例（68．29％）。结论染色体异常是导致反复流产的一个重要原因，RSA 不仅与染色体结构异常相关，而且可能与染色体多态性变异存在一定关系。
목적：통과대엄주지구복발성자연유산（RSA）부부진행염색체핵형분석，탐토 RSA 여염색체이상적관계。방법대엄주지구394대 RSA 부부외주혈주림파세포배양병진행염색체핵형분석。결과394대 RSA 부부중，염색체이상41례，이상솔위5．2％，기중염색체수목이상1례（2．44％），평형역위8례（19．51％），라백손역위3례（7．32％），염색체도위1례（2．44％），염색체다태변이28례（68．29％）。결론염색체이상시도치반복유산적일개중요원인，RSA 불부여염색체결구이상상관，이차가능여염색체다태성변이존재일정관계。
Objective To explore the relationship between recurrent spontaneous abortion and the chromosome abnormality by analyzing the 394 couples′chromosome karyotypes.Methods Peripheral blood lymphocytes in 394 couples of recurrent spontane-ous abortion in Guangzhou area were cultured and performed the chromosome karyotype analysis.Results Among 394 couples of recrudescence abortion,41 cases (5.2%)of abnormal chromosome karyotypes were detected including 1 case(2.44%)of chromo-some number abnormality,8 cases (19.51 %)of balanced translocation,3 cases (7.32%)of Robertsonian translocation,1 case (2.44%)of chromosome inversion and 28 cases (68.29%)of chromosomal polymorphism.Conclusion The chromosomal abnor-mality is an important reason for recurrent spontaneous abortion.Recurrent spontaneous abortion is not only associated with anoma-lies of chromosome structure,and could have a certain relationship with chromosome polymorphism.