国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
1期
47-48
,共2页
肝炎抗体,丙型%肝纤指标
肝炎抗體,丙型%肝纖指標
간염항체,병형%간섬지표
hepatitis antibodies%C type%fibrosis indexes
目的：探讨丙型肝炎患者 RNA 水平与抗-HCV 抗体和肝纤指标水平的关系。方法收集96例慢性丙型肝炎患者的血清，实时荧光定量 PCR 测定 HCV-RNA 和 ELISA 法检测抗-HCV 抗体。化学发光法检测 LN、PCⅢ、CⅣ及放免法检测 HA。并对抗-HCV 抗体、HCV-RNA 水平与血清肝纤指标之间的关系进行分析。结果本研究的96例抗-HCV 抗体阳性的慢性丙型肝炎患者中，HCV-RNA 阳性52例，阳性率为54．2％。随着抗-HCV 抗体的 S／CO 值升高，HCV-RNA 检出率也在增高，分别为9．5％、37．1％和92．5％。高病毒载量组与低病毒载量组比较，血清 HA、LN、PCⅢ及 CⅣ水平的差异无统计学意义（P ＞0．05）。结论慢性丙肝患者 HCV-RNA 阳性检出率与抗-HCV 抗体的 S／CO 值有关，S／CO 值越高，HCV-RNA 阳性率越高。而 RNA水平与肝纤指标水平没有相关性。
目的：探討丙型肝炎患者 RNA 水平與抗-HCV 抗體和肝纖指標水平的關繫。方法收集96例慢性丙型肝炎患者的血清，實時熒光定量 PCR 測定 HCV-RNA 和 ELISA 法檢測抗-HCV 抗體。化學髮光法檢測 LN、PCⅢ、CⅣ及放免法檢測 HA。併對抗-HCV 抗體、HCV-RNA 水平與血清肝纖指標之間的關繫進行分析。結果本研究的96例抗-HCV 抗體暘性的慢性丙型肝炎患者中，HCV-RNA 暘性52例，暘性率為54．2％。隨著抗-HCV 抗體的 S／CO 值升高，HCV-RNA 檢齣率也在增高，分彆為9．5％、37．1％和92．5％。高病毒載量組與低病毒載量組比較，血清 HA、LN、PCⅢ及 CⅣ水平的差異無統計學意義（P ＞0．05）。結論慢性丙肝患者 HCV-RNA 暘性檢齣率與抗-HCV 抗體的 S／CO 值有關，S／CO 值越高，HCV-RNA 暘性率越高。而 RNA水平與肝纖指標水平沒有相關性。
목적：탐토병형간염환자 RNA 수평여항-HCV 항체화간섬지표수평적관계。방법수집96례만성병형간염환자적혈청，실시형광정량 PCR 측정 HCV-RNA 화 ELISA 법검측항-HCV 항체。화학발광법검측 LN、PCⅢ、CⅣ급방면법검측 HA。병대항-HCV 항체、HCV-RNA 수평여혈청간섬지표지간적관계진행분석。결과본연구적96례항-HCV 항체양성적만성병형간염환자중，HCV-RNA 양성52례，양성솔위54．2％。수착항-HCV 항체적 S／CO 치승고，HCV-RNA 검출솔야재증고，분별위9．5％、37．1％화92．5％。고병독재량조여저병독재량조비교，혈청 HA、LN、PCⅢ급 CⅣ수평적차이무통계학의의（P ＞0．05）。결론만성병간환자 HCV-RNA 양성검출솔여항-HCV 항체적 S／CO 치유관，S／CO 치월고，HCV-RNA 양성솔월고。이 RNA수평여간섬지표수평몰유상관성。
Objective To investigate the correlation between serum HCV-RNA level and anti-HCV with liver fibrosis indexes in the patients with chronic hepatitis C.Methods The serum samples were collected in 96 cases of chronic hepatitis C.The HCV-RNA level was determined by real time fluorescence quantification PCR and Anti-HCV was detected by ELISA.LN,PCⅢ and CⅣlevels were detected by the electrochemical iuminescence analyzer and HA was examined by radioimmunoassay(RIA).The correla-tion between the HCV-RNA and Anti-HCV levels with the liver fibrosis indexes was analyzed with the statistic software.Results Among these 96 cases of Anti-HCV positive chronic hepatitis C,52 cases (54.2%)were HCV-RNA positive.With increasing of the S/CO value of Anti-HCV,the detection rate of HCV-RNA was increased,which were 9.5%,37.1% and 92.5%.The differ-ences in HA,LN,PCⅢ and CⅣ levels between the high viral load group and the low viral load group had no statistical significance (P >0.05).Conclusion The positive detection rate of HCV-RNA is related with the S/CO value of Anti-HCV,the higher the S/CO value,the higher the positive detection rate of HCV-RNA.But the HCV-RNA level has no correlation with the liver fibrosis in-dexes.
