CAJ | 학술논문

生物乙醇是一种高效、清洁、安全的能源。酿酒酵母（S. cerevisiae）由于其生理特性而在生物乙醇发酵中广泛应用。利用动态通量平衡分析（DFBA）预测模拟了利用葡萄糖发酵产乙醇工艺中的关键参数，生物量、残糖浓度和乙醇生成。预测值与发酵实测值能够较好吻合。该方法为发酵工艺优化提供了计算机模拟优化的方法，也为利用其他底物，如纤维素、木糖等生物质发酵乙醇的理论模拟提供基础。
생물을순시일충고효、청길、안전적능원。양주효모（S. cerevisiae）유우기생리특성이재생물을순발효중엄범응용。이용동태통량평형분석（DFBA）예측모의료이용포도당발효산을순공예중적관건삼수，생물량、잔당농도화을순생성。예측치여발효실측치능구교호문합。해방법위발효공예우화제공료계산궤모의우화적방법，야위이용기타저물，여섬유소、목당등생물질발효을순적이론모의제공기출。
Bio-ethanol is a kind of safe, clean and high efficiency energy. S. cerevisiae has been widely used in bio-ethanol fermentation be-cause of its specific physiological properties. Flux balance analysis is a constraint-based computational tool using genome-scale metabolic net-work to predict intracellular fluxes. In this study, the dynamic flux balance analysis was used to simulate key parameters in bio-ethanol biopro-cess by using glucose as the unique carbon resource, such as biomass, residual glucose concentration and ethanol productivity. The affordable difference between simulated values and measured values indicated that this model could be successfully applied in this simple bioprocess. This work not only provided a computational simulation method in the prediction of bio-ethanol bioprocess, but also established the foundation of the theoretical simulation of ligno-cellulosic bio-ethanol fermentation.