CAJ | 학술논문

目的：分析非小细胞肺癌晚期患者GP方案化疗3周期前后血糖的差异。方法将44名非小细胞肺癌晚期患者根据血糖情况分为血糖正常组和血糖升高组：血糖正常组32例患者直接用GP方案化疗3周期，血糖升高组12例患者予以饮食、运动及胰岛素干预后，再进行GP方案化疗3周期，化疗前后行口服葡萄糖耐量试验、C肽及胰岛素释放试验。结果化疗前血糖正常者经GP方案化疗3周期后25%(8/32)的患者出现血糖升高，而糖调节受损患者化疗后出现一半的患者转变为糖尿病患者。化疗后血糖升高者与血糖正常者比较谷草转氨酶及C反应蛋白差异有统计学意义(P<0．05)。结论 GP方案可致部分非小细胞肺癌晚期患者糖代谢障碍而血糖升高，谷草转氨酶及C反应蛋白异常及胰岛功能差者更容易出现血糖升高。
목적：분석비소세포폐암만기환자GP방안화료3주기전후혈당적차이。방법장44명비소세포폐암만기환자근거혈당정황분위혈당정상조화혈당승고조：혈당정상조32례환자직접용GP방안화료3주기，혈당승고조12례환자여이음식、운동급이도소간예후，재진행GP방안화료3주기，화료전후행구복포도당내량시험、C태급이도소석방시험。결과화료전혈당정상자경GP방안화료3주기후25%(8/32)적환자출현혈당승고，이당조절수손환자화료후출현일반적환자전변위당뇨병환자。화료후혈당승고자여혈당정상자비교곡초전안매급C반응단백차이유통계학의의(P<0．05)。결론 GP방안가치부분비소세포폐암만기환자당대사장애이혈당승고，곡초전안매급C반응단백이상급이도공능차자경용역출현혈당승고。
Objective To evaluate blood glucose differences before and after three cycles of chemotherapy in patients with advanced non-small cell lung cancer. Methods 44 patients with advanced non-small cell lung cancer conducted blood routine,bi-ochemical,and C-reactive protein test;Normal blood glucose group treated chemotherapy with GP 3 cycles,high blood sugar groups measured blood glucose by oral glucose tolerance test,then were on diets,exercised or injected insulin. After GP regimen of 3 cy-cles,blood analysis,biochemical,C-reactive protein,oral glucose tolerance test,c-peptide and insulin release test were measured. Results After 3 cycles of GP,25%(8/32) of patients with normal glucose appears abnormal,and half of patients with abnormal glucose tolerance turn into diabetic. After chemotherapy,aspartate aminotransferase and C-reactive protein were significantly differ-ent from the patients with increased blood glucose and normal blodd glucose,the difference was statistically significant(P<0. 05). Conclusion GP regimen could cause glucose metabolism disorders in some patients with advanced non-small cell lung cancer and even induce diabetes. Patients with abnormal aspartate aminotransferase and C-reactive protein are susceptible to elevate blood glu-cose.