CAJ | 학술논문

目的：观察益气扶元颗粒治疗 III 度以下精索静脉曲张性不育症患者的临床疗效。方法：将88例 III 度以下精索静脉曲张性不育症患者随机分为治疗组45例和对照组43例，治疗组给予益气扶元颗粒（免煎颗粒），2次／d，每次1袋，开水冲服；对照组给予左卡尼汀口服液（瓶），2次／d，每次2瓶，口服；两组共治疗12周治疗结束后随访24周。比较两组患者的临床疗效，精液质量[包括精液量、精子密度、精子活率、前向运动精子（PR）及精子畸形率]，测定治疗前后左侧精索静脉管径的变化，随访观察患者配偶受孕情况，结果：两组治愈率（治疗组6.67％，对照组6.97％）比较，差异无统计学意义（P ＞0.05）；治疗组显效率（55.56％）、有效率（24.44％）、总有效率（86.66％）与对照组（分别为41.86％、20.90％、76.74％）比较，差异有统计学意义（P ＜0.05），治疗组优于对照组。两组患者治疗后精液量、精子密度、精子活率、PR 比治疗前提高，精子畸形率均比治疗前降低（P ＜0.05）；并且治疗后治疗组精子密度、PR 均高于对照组（P ＜0.05）两组治疗后亚临床型、I 度、II 度左侧精索静脉管径，治疗组比治疗前缩窄（P ＜0.05），对照组（P ＞0.05）；治疗24周后随访，患者配偶共有6例确诊怀孕，其中治疗组 3例，对照组 3例。结论：益气扶元颗粒能够提高三度以下精索静脉曲张性不育患者的精液质量，缩窄亚临床型、I 度、II 度精索静脉管径。
목적：관찰익기부원과립치료 III 도이하정색정맥곡장성불육증환자적림상료효。방법：장88례 III 도이하정색정맥곡장성불육증환자수궤분위치료조45례화대조조43례，치료조급여익기부원과립（면전과립），2차／d，매차1대，개수충복；대조조급여좌잡니정구복액（병），2차／d，매차2병，구복；량조공치료12주치료결속후수방24주。비교량조환자적림상료효，정액질량[포괄정액량、정자밀도、정자활솔、전향운동정자（PR）급정자기형솔]，측정치료전후좌측정색정맥관경적변화，수방관찰환자배우수잉정황，결과：량조치유솔（치료조6.67％，대조조6.97％）비교，차이무통계학의의（P ＞0.05）；치료조현효솔（55.56％）、유효솔（24.44％）、총유효솔（86.66％）여대조조（분별위41.86％、20.90％、76.74％）비교，차이유통계학의의（P ＜0.05），치료조우우대조조。량조환자치료후정액량、정자밀도、정자활솔、PR 비치료전제고，정자기형솔균비치료전강저（P ＜0.05）；병차치료후치료조정자밀도、PR 균고우대조조（P ＜0.05）량조치료후아림상형、I 도、II 도좌측정색정맥관경，치료조비치료전축착（P ＜0.05），대조조（P ＞0.05）；치료24주후수방，환자배우공유6례학진부잉，기중치료조 3례，대조조 3례。결론：익기부원과립능구제고삼도이하정색정맥곡장성불육환자적정액질량，축착아림상형、I 도、II 도정색정맥관경。
Objectives:To observe the therapeutic effect of Yiqi Fuyuan Granule treatment on infertility pa-tients with Varicocele -below three degrees.Methods:88 infertility patients with Varicocele -below three degrees were divided into the treatment group and control group randomly,with 45 in treatment group and 43 in control group. The treatment group was given Yiqi Fuyuan granular treatment,2 times a day.The control group was given levocarni-tine oral solution,2 times a day.The treatment course lasted for 12 weeks,followed by 24 weeks follow -up.The therapeutic effect and semen quality was observed after treatment.The diameter of left spermatic vein was measured by color doppler ultrasound before and after treatment.Results:The cure rates of the treatment group and control group were 6.67% and 6.97% respectively,with no significant difference (P >0.05).The markedly effective rate,effec-tive rate and total effective rate was 55.56% ,24.44% and 86.66% respectively,which was superior to 41.86%, 20.90% and 76.74% in the control group,with statistically significant difference (P <0.05).The semen volume, sperm concentration,sperm motility and progressive motility (PR)was significantly increased and sperm abnormality rate was significantly reduced in both groups after treatment (P <0.05).The diameter of left spermatic vein was nar-rowed after treatment in patients with subclinical,1 and 2 degree varicocele in the treatment groups (P <0.05)but the control group (P >0.05).The patients were followed up for 24 weeks after treatment and there were 6 patients (3 patients in the treatment group and 3 in the control group)whose sexual partners got pregnant.Conclusion:Yiqi Fuyuan granule treatment can improve the semen quality in infertility patients with varicocele -below three degrees and narrow the diameter of spermatic vein in patients with subclinical,1 and 2 degree varicocele.