CAJ | 학술논문

目的：探讨缬沙坦联合阿托伐他汀治疗慢性肾炎的临床疗效。方法将168例慢性肾炎患者随机分入A组与B组，两组患者均接受慢性肾炎常规治疗。 A组患者同时接受口服缬沙坦，B组患者接受缬沙坦及阿托伐他汀口服，疗程12月。比较两组治疗前后肾功能、24 h尿蛋白定量、超敏C反应蛋白、肾小球滤过率（ GFR）、血脂、血压、肝功能及肌酶等差别。结果治疗12个月后，B组hs-CRP、24h尿蛋白显著优于A组（P＜0．05），B组胆固醇及低密度脂蛋白显著降低（P＜0．05），两组收缩压、舒张压、肝功能、肌酶水平比较差异无统计学意义（P＞0．05）。结论缬沙坦联合阿托伐他汀治疗慢性肾炎可显著降低CRP水平并减少尿蛋白，有利于延缓病情。
목적：탐토힐사탄연합아탁벌타정치료만성신염적림상료효。방법장168례만성신염환자수궤분입A조여B조，량조환자균접수만성신염상규치료。 A조환자동시접수구복힐사탄，B조환자접수힐사탄급아탁벌타정구복，료정12월。비교량조치료전후신공능、24 h뇨단백정량、초민C반응단백、신소구려과솔（ GFR）、혈지、혈압、간공능급기매등차별。결과치료12개월후，B조hs-CRP、24h뇨단백현저우우A조（P＜0．05），B조담고순급저밀도지단백현저강저（P＜0．05），량조수축압、서장압、간공능、기매수평비교차이무통계학의의（P＞0．05）。결론힐사탄연합아탁벌타정치료만성신염가현저강저CRP수평병감소뇨단백，유리우연완병정。
Objective To examine the clinical effect of valsartan combined with atorvastatin in the treatment of chronic nephritis.Method 168 cases of chronic nephritis were randomly divided into two groups , group A and group B.Both groups were firstly given conventional treatment .Group A were treated with oral valsartan while group B were given valsartan and atorvastatin therapy .The length of treatment was 12 months.The change of renal function , 24h urine protein, hs-CRP, GFR, blood lipid, blood pressure, liver function and enzyme before and after treatment in the two groups were compared.Findings After treatment, hs-CRP and 24h urine protein in group B were superior to those in group A (P<0.05);TC and LDL-C after treatment in group B significantly decreased (P<0.05).No significant change was found in group A (P>0.05);The difference between the two groups in systolic pressure , diastolic pressure, liver function, muscle enzyme levels was not significant (P>0.05).Conclusion Valsartan combined with atorvastatin for chronic nephritis can greatly decrease the level of CRP and urine protein and delay the occurrence of disease .