中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2015年
1期
55-58
,共4页
马笑堃%王庆祝%秦贵军%赵艳艳%张颖辉%马晓君%李志臻%王志敏%任高飞
馬笑堃%王慶祝%秦貴軍%趙豔豔%張穎輝%馬曉君%李誌臻%王誌敏%任高飛
마소곤%왕경축%진귀군%조염염%장영휘%마효군%리지진%왕지민%임고비
糖尿病%丙氨酸转氨酶%乙醇%γ-谷氨酰转移酶
糖尿病%丙氨痠轉氨酶%乙醇%γ-穀氨酰轉移酶
당뇨병%병안산전안매%을순%γ-곡안선전이매
Diabetes mellitus%Alanine aminotransferase%Alcohol%γ-Glutamyltransferase
目的 探讨血清肝酶联合乙醇摄入量对2型糖尿病(T2DM)发病的预测价值. 方法 选取郑州市社区调查的2 693名男性,记录其身高、体质量、吸烟史、饮酒史,检测血清ALT、AST、y-谷氨酰转移酶(GGT)、血糖及相关代谢指标.两组间均数比较采用独立样本t检验,率的比较采用x2检验;两组间连续性变量应用Pearson相关分析,等级变量应用Spearman相关分析;参数分析采用二项分类logistic回归分析. 结果 适度饮酒(每周摄入乙醇量＞35g且＜140 g)减少T2DM的发病风险[比值比(OR)=0.376,95％可信区间(CI)为0.306～ 0.463,P＜0.05)].血清GGT和ALT水平升高增加T2DM的发病风险(GGT:OR-3.012,95％ CI为2.357 ～ 3.849,P＜0.01;ALT:OR=1.473,95％ CI为1.043 ～ 2.081,P＜0.05).不饮酒或少量饮酒(每周摄入乙醇量≤35 g)且GGT位于第四分位间距水平组发生T2DM的风险最高(OR=12.219,95％CI为6.217 ～ 24.016,P＜0.01).ALT和乙醇摄入量与T2DM发病之间的关系和GGT类似(不饮酒或少量饮酒且ALT位于第四分位间距水平组,OR=5.357,95％ CI为3.070 ～ 9.350,P＜0.01). 结论 GGT、ALT、乙醇摄入量分别与T2DM发病相关.不饮酒或少量饮酒而GGT或ALT升高者发生T2DM的相对危险较高.
目的 探討血清肝酶聯閤乙醇攝入量對2型糖尿病(T2DM)髮病的預測價值. 方法 選取鄭州市社區調查的2 693名男性,記錄其身高、體質量、吸煙史、飲酒史,檢測血清ALT、AST、y-穀氨酰轉移酶(GGT)、血糖及相關代謝指標.兩組間均數比較採用獨立樣本t檢驗,率的比較採用x2檢驗;兩組間連續性變量應用Pearson相關分析,等級變量應用Spearman相關分析;參數分析採用二項分類logistic迴歸分析. 結果 適度飲酒(每週攝入乙醇量＞35g且＜140 g)減少T2DM的髮病風險[比值比(OR)=0.376,95％可信區間(CI)為0.306～ 0.463,P＜0.05)].血清GGT和ALT水平升高增加T2DM的髮病風險(GGT:OR-3.012,95％ CI為2.357 ～ 3.849,P＜0.01;ALT:OR=1.473,95％ CI為1.043 ～ 2.081,P＜0.05).不飲酒或少量飲酒(每週攝入乙醇量≤35 g)且GGT位于第四分位間距水平組髮生T2DM的風險最高(OR=12.219,95％CI為6.217 ～ 24.016,P＜0.01).ALT和乙醇攝入量與T2DM髮病之間的關繫和GGT類似(不飲酒或少量飲酒且ALT位于第四分位間距水平組,OR=5.357,95％ CI為3.070 ～ 9.350,P＜0.01). 結論 GGT、ALT、乙醇攝入量分彆與T2DM髮病相關.不飲酒或少量飲酒而GGT或ALT升高者髮生T2DM的相對危險較高.
목적 탐토혈청간매연합을순섭입량대2형당뇨병(T2DM)발병적예측개치. 방법 선취정주시사구조사적2 693명남성,기록기신고、체질량、흡연사、음주사,검측혈청ALT、AST、y-곡안선전이매(GGT)、혈당급상관대사지표.량조간균수비교채용독립양본t검험,솔적비교채용x2검험;량조간련속성변량응용Pearson상관분석,등급변량응용Spearman상관분석;삼수분석채용이항분류logistic회귀분석. 결과 괄도음주(매주섭입을순량＞35g차＜140 g)감소T2DM적발병풍험[비치비(OR)=0.376,95％가신구간(CI)위0.306～ 0.463,P＜0.05)].혈청GGT화ALT수평승고증가T2DM적발병풍험(GGT:OR-3.012,95％ CI위2.357 ～ 3.849,P＜0.01;ALT:OR=1.473,95％ CI위1.043 ～ 2.081,P＜0.05).불음주혹소량음주(매주섭입을순량≤35 g)차GGT위우제사분위간거수평조발생T2DM적풍험최고(OR=12.219,95％CI위6.217 ～ 24.016,P＜0.01).ALT화을순섭입량여T2DM발병지간적관계화GGT유사(불음주혹소량음주차ALT위우제사분위간거수평조,OR=5.357,95％ CI위3.070 ～ 9.350,P＜0.01). 결론 GGT、ALT、을순섭입량분별여T2DM발병상관.불음주혹소량음주이GGT혹ALT승고자발생T2DM적상대위험교고.
Objective To compare the predictive value of liver enzymes and alcohol consumption for determining risk of type 2 diabetes (T2DM).Methods A cross-sectional study was conducted in Zhengzhou with a total of 2,693 men.Participants' height,weight,and histories of smoking and drinking were recorded.Levels of alanine aminotransferase (ALT),aspartate aminotransferase (AST),γ-glutamyl transferase (GGT) and blood glucose,as well as related metabolic indexes were detected.Results Moderate daily alcohol consumption (＞ 35 g ethanol/week and ＜ 140 g ethanol/week) decreased the risk of type 2 diabetes (OR =0.376,95％ CI:0.306 -0.463,P ＜ 0.05) but increased risk for higher levels of GGT and ALT (OR GGT =3.012,95％ CI:2.357-3.849,P＜ 0.01; ORALT =1.473,95％ CI:1.043-2.081,P＜ 0.05).In joint analyses of alcohol consumption and liver enzymes,the group of nondrinkers/light drinkers (≤ 35 g ethanol/week) in the fourth quartile of GGT levels had the highest risk for type 2 diabetes (OR =12.219,95％ CI:6.217-24.016,P ＜ 0.01).The relationship of ALT and daily alcohol consumption with the risk of type 2 diabetes was almost the same as that of GGT (nondrinkers/light drinkers in the fourth quartile of ALT levels (OR =5.357,95％ CI:3.070-9.350,P ＜ 0.0 1).Conclusion GGT,ALT and daily alcohol consumption were independently associated with risk of type 2 diabetes.Nondrinkers/light drinkers with the highest levels ofGGT orALT were at high risk of type 2 diabetes.
