中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2015年
1期
55-59
,共5页
龚奎玉%陈晨%郭素萍%夏云飞
龔奎玉%陳晨%郭素萍%夏雲飛
공규옥%진신%곽소평%하운비
鼻咽肿瘤/放射疗法%乳酸脱氢酶%预后
鼻嚥腫瘤/放射療法%乳痠脫氫酶%預後
비인종류/방사요법%유산탈경매%예후
Nasopharyngeal neoplasms/radiotherapy%Lactate dehydrogense%Prognosis
目的 了解疗前血清LDH水平在鼻咽癌各放疗分型中分布及对预后影响.方法 搜集中山大学肿瘤防治中心2000-2005年初治鼻咽癌患者2665例资料,对疗前血清LDH检测值在放疗4种分型中变化及其与生存关系进行分析.结果 2 665例患者各放疗分型分布分别为Ⅰ型(放射敏感不易转移型)1 987例(74.6％)、Ⅱ型(放射抗拒不易转移型)404例(15.1％)、Ⅲ型(放射敏感易转移型)229例(8.6％)、Ⅳ型(放射抗拒易转型移型)45例(1.7％).LDH升高者在4个分型所占比例分别为9.6％(191/1 987)、15.8％ (64/404)、18.8％(43/229)、35.6％(16/45);Ⅲ、Ⅳ型转移患者共274例,其81例肝转移者中LDH升高者占42％(34例).总随访率为95.2％.总体LDH升高组的OS、LRFS、DMFS曲线均差于LDH正常组(P=0.000、0.000、0.000),而4个放疗分型中只有Ⅱ型OS的差异有统计学意义(P=0.000).结论 疗前血清LDH水平升高与鼻咽癌放疗分型相关,在Ⅲ、Ⅳ型患者中LDH升高以肝转移更明显,LDH升高预后变差主要表现在Ⅱ型患者.
目的 瞭解療前血清LDH水平在鼻嚥癌各放療分型中分佈及對預後影響.方法 搜集中山大學腫瘤防治中心2000-2005年初治鼻嚥癌患者2665例資料,對療前血清LDH檢測值在放療4種分型中變化及其與生存關繫進行分析.結果 2 665例患者各放療分型分佈分彆為Ⅰ型(放射敏感不易轉移型)1 987例(74.6％)、Ⅱ型(放射抗拒不易轉移型)404例(15.1％)、Ⅲ型(放射敏感易轉移型)229例(8.6％)、Ⅳ型(放射抗拒易轉型移型)45例(1.7％).LDH升高者在4箇分型所佔比例分彆為9.6％(191/1 987)、15.8％ (64/404)、18.8％(43/229)、35.6％(16/45);Ⅲ、Ⅳ型轉移患者共274例,其81例肝轉移者中LDH升高者佔42％(34例).總隨訪率為95.2％.總體LDH升高組的OS、LRFS、DMFS麯線均差于LDH正常組(P=0.000、0.000、0.000),而4箇放療分型中隻有Ⅱ型OS的差異有統計學意義(P=0.000).結論 療前血清LDH水平升高與鼻嚥癌放療分型相關,在Ⅲ、Ⅳ型患者中LDH升高以肝轉移更明顯,LDH升高預後變差主要錶現在Ⅱ型患者.
목적 료해료전혈청LDH수평재비인암각방료분형중분포급대예후영향.방법 수집중산대학종류방치중심2000-2005년초치비인암환자2665례자료,대료전혈청LDH검측치재방료4충분형중변화급기여생존관계진행분석.결과 2 665례환자각방료분형분포분별위Ⅰ형(방사민감불역전이형)1 987례(74.6％)、Ⅱ형(방사항거불역전이형)404례(15.1％)、Ⅲ형(방사민감역전이형)229례(8.6％)、Ⅳ형(방사항거역전형이형)45례(1.7％).LDH승고자재4개분형소점비례분별위9.6％(191/1 987)、15.8％ (64/404)、18.8％(43/229)、35.6％(16/45);Ⅲ、Ⅳ형전이환자공274례,기81례간전이자중LDH승고자점42％(34례).총수방솔위95.2％.총체LDH승고조적OS、LRFS、DMFS곡선균차우LDH정상조(P=0.000、0.000、0.000),이4개방료분형중지유Ⅱ형OS적차이유통계학의의(P=0.000).결론 료전혈청LDH수평승고여비인암방료분형상관,재Ⅲ、Ⅳ형환자중LDH승고이간전이경명현,LDH승고예후변차주요표현재Ⅱ형환자.
Objective This aim of this study was to understand the distribution of pretreatment serum LDH in NPC of each radiotherapy-related typing,and its relationship with prognosis.Methods We collected the pretreatment data of LDH in 2 665 newly diagnosed NPC who underwent radical radiotherapy between January 1,2000 and December 31,2005 at Sun Yat-sen University Cancer Center.Pretreatment serum LDH levels and survival analysis were analyzed in four kinds of radiotherapy-related typing of NPC.Results Distribution of radiotherapy-related types of 2 665 NPC were 74.6％ (1 987 cases),15.1％ (404 cases),8.6％ (229 cases),1.7％ (45 cases) for Types Ⅰ (no primary and regional recurrence and no distant metastasis),Ⅱ (primary or regional and no distant metastasis),ⅢⅡ (no primary and regional recurrence,and distant metastasis),Ⅳ (primary or regional recurrence,and distant metastasis),respectively.Increased LDH patients Ⅰ,Ⅱ,Ⅲ,Ⅳ-type proportion were:9.6％ (191/1 987),15.8％ (64/404),18.8％ (43/229),35.6％ (16/45).274 cases of type Ⅲ and Ⅳ,there were 81 cases of liver metastasis,which increased LDH levels in 34 cases,accounted for 42％.Total follow-up rate was 95.2％.The OS,LRFS,and DMFS curves for the increased LDH level group and the normal LDH level group was significant (P =0.000,0.000,0.000).Further analysis showed that the above main difference caused by the type Ⅱ (P =0.000).Conclusions Pretreatment levels of serum LDH are associated with radiotherapyrelated typing of NPC,particularly associated with type Ⅲ and type Ⅳ liver metastasis.And mainly type Ⅱ has poor prognosis.
