中华儿科杂志
中華兒科雜誌
중화인과잡지
Chinese Journal of Pediatrics
2015年
2期
129-135
,共7页
空气污染%颗粒物%儿童%哮喘%住院病人%Meta分析
空氣汙染%顆粒物%兒童%哮喘%住院病人%Meta分析
공기오염%과립물%인동%효천%주원병인%Meta분석
Air pollution%Particulate matter%Child%Asthma%Inpatients%Meta-analysis
目的 评价大气颗粒物(PM10、PM2.5)短期暴露对儿童哮喘发作住院人数的影响,获取大气颗粒物与儿童哮喘发作的暴露-反应关系.方法 检索PubMed、Ebsco、Ovid、中国生物医学数据库、中文科技期刊全文数据库、中国知网和万方数据库等,检索时间均为1990年1月1日至2013年12月31日,以“哮喘”“PM10”“PM25”“空气污染”“颗粒物”及“asthma”“air pollution" "air pollutants”“particulate matter”为关键词查找关于颗粒物短期暴露对儿童哮喘住院人数影响的文献.依据文献纳入和排除标准及制定的评价标准,进行文献筛选和质量评价.纳入文献后分别提取PM10、PM25的暴露-反应关系,采用Revman5.2.11软件进行Meta分析,根据异质性结果选择相应的效应模型分析.结果 大气中PM10浓度每上升10μg/m3,短期内儿童哮喘的住院人数平均上升1.75％,而PM25浓度每上升10 μg/m3,短期内儿童哮喘的住院人数平均上升3.45％;亚组分析中病例交叉研究的暴露-反应关系效应值高于时间序列分析.结论 短期内PM10、PM2.5浓度的上升会导致儿童哮喘住院人数增加,且PM2.5引起的发作风险高于PM10.
目的 評價大氣顆粒物(PM10、PM2.5)短期暴露對兒童哮喘髮作住院人數的影響,穫取大氣顆粒物與兒童哮喘髮作的暴露-反應關繫.方法 檢索PubMed、Ebsco、Ovid、中國生物醫學數據庫、中文科技期刊全文數據庫、中國知網和萬方數據庫等,檢索時間均為1990年1月1日至2013年12月31日,以“哮喘”“PM10”“PM25”“空氣汙染”“顆粒物”及“asthma”“air pollution" "air pollutants”“particulate matter”為關鍵詞查找關于顆粒物短期暴露對兒童哮喘住院人數影響的文獻.依據文獻納入和排除標準及製定的評價標準,進行文獻篩選和質量評價.納入文獻後分彆提取PM10、PM25的暴露-反應關繫,採用Revman5.2.11軟件進行Meta分析,根據異質性結果選擇相應的效應模型分析.結果 大氣中PM10濃度每上升10μg/m3,短期內兒童哮喘的住院人數平均上升1.75％,而PM25濃度每上升10 μg/m3,短期內兒童哮喘的住院人數平均上升3.45％;亞組分析中病例交扠研究的暴露-反應關繫效應值高于時間序列分析.結論 短期內PM10、PM2.5濃度的上升會導緻兒童哮喘住院人數增加,且PM2.5引起的髮作風險高于PM10.
목적 평개대기과립물(PM10、PM2.5)단기폭로대인동효천발작주원인수적영향,획취대기과립물여인동효천발작적폭로-반응관계.방법 검색PubMed、Ebsco、Ovid、중국생물의학수거고、중문과기기간전문수거고、중국지망화만방수거고등,검색시간균위1990년1월1일지2013년12월31일,이“효천”“PM10”“PM25”“공기오염”“과립물”급“asthma”“air pollution" "air pollutants”“particulate matter”위관건사사조관우과립물단기폭로대인동효천주원인수영향적문헌.의거문헌납입화배제표준급제정적평개표준,진행문헌사선화질량평개.납입문헌후분별제취PM10、PM25적폭로-반응관계,채용Revman5.2.11연건진행Meta분석,근거이질성결과선택상응적효응모형분석.결과 대기중PM10농도매상승10μg/m3,단기내인동효천적주원인수평균상승1.75％,이PM25농도매상승10 μg/m3,단기내인동효천적주원인수평균상승3.45％;아조분석중병례교차연구적폭로-반응관계효응치고우시간서렬분석.결론 단기내PM10、PM2.5농도적상승회도치인동효천주원인수증가,차PM2.5인기적발작풍험고우PM10.
Objective To systematically review and assess the relationship between particulate matter (PM10 and PM2.5) and children's hospital admissions for asthma,using both time-series and casecrossover analyses.Method The PubMed,Ebsco,Ovid and four Chinese periodical databases were screened for studies related to short-term effects of particulate matter on pediatric asthma hospital admissions published from 1 January 1990 to 31 December 2013.Sixteen studies on PM10 and 10 studies on PM2.5 were selected finally for meta-analysis.Relative risk (RR) or odds ratio(OR) and 95％ confidence intervals (CI) of asthrua hospital admissions per 10 μg/m3 increase of daily particulate matter were obtained from each study.RevMan 5.2.11 was used to test the heterogeneity of the results among the different studies and amalgamat the effect size by fixed or random effect model.Result As the concentration of PM10 increased per 10 μg/m3,the children's hospital admissions for asthma increased by 1.75％ ; for PM2.5,a 3.45％ increase for asthma hospital admissions as the concentration increased per 10.μg/m3.By subgroup analysis based on study design,the effect size on both PM10 and PM2.5 of case-crossover study's results were higher than time-series analysis.Conclusion The short-term increase of the concentration of PM10 and PM2.5 may led to the increase of Children's hospital admissions for asthma,and PM2.5 will present a higher risk contribution.
