CAJ | 학술논문

孕妇血清乙型肝炎病毒（hepatitis B virus， HBV）DNA水平目前被认为是预测发生HBV母婴垂直传播的一个最重要指标和独立的危险因素。普遍认为，在充分考虑对孕妇及胎儿的利与弊的前提下，妊娠中、晚期口服安全性较高的核苷（酸）类抗病毒药物，可在分娩前明显降低母血中HBV DNA载量，从而最大程度地阻断HBV母婴垂直传播。抗病毒治疗4周后监测HBV DNA载量可以预估核苷（酸）类药物抗病毒治疗的远期有效性，以便及时调整治疗方案。 HBV DNA检测在孕期的应用与何时应用对阻断HBV母婴垂直传播具有重要意义。
잉부혈청을형간염병독（hepatitis B virus， HBV）DNA수평목전피인위시예측발생HBV모영수직전파적일개최중요지표화독립적위험인소。보편인위，재충분고필대잉부급태인적리여폐적전제하，임신중、만기구복안전성교고적핵감（산）류항병독약물，가재분면전명현강저모혈중HBV DNA재량，종이최대정도지조단HBV모영수직전파。항병독치료4주후감측HBV DNA재량가이예고핵감（산）류약물항병독치료적원기유효성，이편급시조정치료방안。 HBV DNA검측재잉기적응용여하시응용대조단HBV모영수직전파구유중요의의。
Maternal serum hepatitis B virus ( HBV) DNA level is considered as the most important and independent risk factor to predict the HBV vertical transmission rates .After fully considered the pros and cons of the mother and fetus , it′s generally agreed that administration of oral nucleoside antiviral in the second and third trimester can significantly reduce maternal serum HBV loads before delivery . Consequently , it will prevent maternal-fetal transmission of HBV to the maximum extent .HBV DNA level at week 4 of antiviral treatment predicts the long-term efficacy , which conduce to improve the therapeutic schedule.Overall, the measurement of HBV DNA level during pregnancy and the optimal time have important meaning for preventing maternal-fetal transmission of HBV .