广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2015年
1期
111-112,139
,共3页
张著森%胡志彪%丘则海%拓宏桂
張著森%鬍誌彪%丘則海%拓宏桂
장저삼%호지표%구칙해%탁굉계
药物分析%尼美舒利%线性扫描极谱法%吸附波
藥物分析%尼美舒利%線性掃描極譜法%吸附波
약물분석%니미서리%선성소묘겁보법%흡부파
pharmaceutical analysis%nimesulide%scanning polarographic%adsorptive wave
用线性扫描极谱法和循环伏安法研究尼美舒利在0.02 mol·L-1 KH2PO4-Na2HPO4缓冲溶液(pH 9.01)中的电化学行为，尼美舒利于-0.782 V( vs. SCE)处产生一灵敏的吸附波，在尼美舒利浓度为0.5~100.0 mg·L-1范围内，其一次微分线性扫描峰电流与尼美舒利浓度呈良好的线性关系，相关系数r=0.9981(n=15)，检出限为0.4 mg·L-1。对100 mg·L-1尼美舒利溶液进行6次平行试验， RSD为1.24％，回收率在97.2％~104.1％之间，方法可用于其在片剂中含量的测定。
用線性掃描極譜法和循環伏安法研究尼美舒利在0.02 mol·L-1 KH2PO4-Na2HPO4緩遲溶液(pH 9.01)中的電化學行為，尼美舒利于-0.782 V( vs. SCE)處產生一靈敏的吸附波，在尼美舒利濃度為0.5~100.0 mg·L-1範圍內，其一次微分線性掃描峰電流與尼美舒利濃度呈良好的線性關繫，相關繫數r=0.9981(n=15)，檢齣限為0.4 mg·L-1。對100 mg·L-1尼美舒利溶液進行6次平行試驗， RSD為1.24％，迴收率在97.2％~104.1％之間，方法可用于其在片劑中含量的測定。
용선성소묘겁보법화순배복안법연구니미서리재0.02 mol·L-1 KH2PO4-Na2HPO4완충용액(pH 9.01)중적전화학행위，니미서리우-0.782 V( vs. SCE)처산생일령민적흡부파，재니미서리농도위0.5~100.0 mg·L-1범위내，기일차미분선성소묘봉전류여니미서리농도정량호적선성관계，상관계수r=0.9981(n=15)，검출한위0.4 mg·L-1。대100 mg·L-1니미서리용액진행6차평행시험， RSD위1.24％，회수솔재97.2％~104.1％지간，방법가용우기재편제중함량적측정。
The electrochemical behavior of Nimesulide was studied in linear scanning polarographic method. In an phosphate buffer solution of pH 9. 01, a sensitive reductive wave of Nimesulide appeared at-0. 782 V ( vs. SCE) . The linear relationship between the peak current and the Nimesulide concentration in the range of 0. 5~100. 0 mg·L-1 ( r=0. 9981 , n=15 ) were observed. The detection limit of the method was 0. 4 mg · L-1 . RSD found from the data of 6 independent determinations at the concentration level of 100. 0 mg · L-1 was 1. 24%. Recoveries obtained were in the range of 97. 2% ~104. 1%. This method was applied to the analysis of Nimesulide in tablets.
