CAJ | 학술논문

调节性非编码RNA是指不被翻译为蛋白且具调节作用的功能性 RNA分子，常见的具调控作用的非编码RNA（ncRNA）包括si RNA、miRNA、piRNA以及长链非编码RNA（lncRNA）．lncRNA是目前调节性非编码RNA研究的热点．lncRN A与物种进化、胚胎发育、物质代谢以及肿瘤发生等有密切的联系，对其功能深入了解可促进细胞内基因表达调控网络的研究，也为临床疾病尤其是肿瘤的诊断和治疗以及新药的研发提供科学依据．本文主要对lncRN A的功能研究以及与疾病的发生研究现状进行探讨．
조절성비편마RNA시지불피번역위단백차구조절작용적공능성 RNA분자，상견적구조공작용적비편마RNA（ncRNA）포괄si RNA、miRNA、piRNA이급장련비편마RNA（lncRNA）．lncRNA시목전조절성비편마RNA연구적열점．lncRN A여물충진화、배태발육、물질대사이급종류발생등유밀절적련계，대기공능심입료해가촉진세포내기인표체조공망락적연구，야위림상질병우기시종류적진단화치료이급신약적연발제공과학의거．본문주요대lncRN A적공능연구이급여질병적발생연구현상진행탐토．
Non-coding RNAs are functional RNA molecules that are not translated into proteins .The main classes of regulatory non-coding RNAs include siRNA ,miRNA ,piRNA and long non-coding RNAs .At present ,long non-coding RNAs (lncRNAs) are hot spots in contrast to other smaller non-coding RNAs . Through researches ,lncRNAs have been found to affect species evolution ,embryonic development ,me-tabolism and tumorigenesis .Research of IncRNAs will make further insights in understanding of gene ex-pression and regulation networks .It also provides scientific evidence for future diagnosis treatment of clini-cal diseases ,especially in human tumors and new drug research and development .In this review ,we have summarized research progress of lncRNAs .