中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
1期
15-16,17
,共3页
大川芎提取物%离子敏感即型凝胶%鼻黏膜给药
大川芎提取物%離子敏感即型凝膠%鼻黏膜給藥
대천궁제취물%리자민감즉형응효%비점막급약
Dachuanxiong extract%ion sensitive in situ gels%nasal mucosal administration
目的：研制大川芎提取物鼻腔给药用离子敏感即型凝胶，并对其毒性进行初步评价。方法以去乙酰结冷胶为凝胶材料，以甘露醇为渗透压调节剂，醋酸洗必泰为防腐剂，制备大川芎提取物鼻腔给药用离子敏感即型凝胶。结果最终处方中去乙酰结冷胶用量是0.4%，甘露醇用量是5%，醋酸洗必泰用量是0.02%。该鼻腔喷雾剂不会对用药者的局部组织产生明显的刺激作用，对蟾蜍上颚黏膜纤毛毒性无明显影响。结论大川芎提取物鼻腔给药用离子敏感即型凝胶的处方初步设计合理，可进一步研究开发。
目的：研製大川芎提取物鼻腔給藥用離子敏感即型凝膠，併對其毒性進行初步評價。方法以去乙酰結冷膠為凝膠材料，以甘露醇為滲透壓調節劑，醋痠洗必泰為防腐劑，製備大川芎提取物鼻腔給藥用離子敏感即型凝膠。結果最終處方中去乙酰結冷膠用量是0.4%，甘露醇用量是5%，醋痠洗必泰用量是0.02%。該鼻腔噴霧劑不會對用藥者的跼部組織產生明顯的刺激作用，對蟾蜍上顎黏膜纖毛毒性無明顯影響。結論大川芎提取物鼻腔給藥用離子敏感即型凝膠的處方初步設計閤理，可進一步研究開髮。
목적：연제대천궁제취물비강급약용리자민감즉형응효，병대기독성진행초보평개。방법이거을선결랭효위응효재료，이감로순위삼투압조절제，작산세필태위방부제，제비대천궁제취물비강급약용리자민감즉형응효。결과최종처방중거을선결랭효용량시0.4%，감로순용량시5%，작산세필태용량시0.02%。해비강분무제불회대용약자적국부조직산생명현적자격작용，대섬서상악점막섬모독성무명현영향。결론대천궁제취물비강급약용리자민감즉형응효적처방초보설계합리，가진일보연구개발。
Objective To research and prepare the ion sensitive in situ gels of Dachuanxiong extract, and to preliminarily evaluate its toxicity. Methods With the deacetylated gellan gum as the gel matrix, mannitol as the osmotic pressure regulator and chlorhexidine acetate as preservative, Dachuanxiong ion sensitive in situ gels for intranasal administration was prepared. Results The quantities of deacetylated gellan gum, mannitol and chlorhexidine acetate were 0. 4%, 5% and 0. 02% respectively. The in situ nasal spray had no obvious stimulation effect on the local tissue and toad palate mucosacilium. Conclusion The preliminary design of ion sensitive in situ gels of Dachuanxiong extract for intranasal administration is reasonable and can be further researched and developed.
