中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
1期
35-36,37
,共3页
氧化应激%氟伐他汀%心血管事件%康复护理干预
氧化應激%氟伐他汀%心血管事件%康複護理榦預
양화응격%불벌타정%심혈관사건%강복호리간예
oxidative stress%fluvastatin%cardiovascular events%rehabilitation nursing intervention
目的：观察氟伐他汀联合康复护理干预对冠状动脉粥样硬化性心脏病（简称冠心病）介入治疗患者氧化应激及再发心血管事件的影响。方法抽选择期首次行冠状动脉介入( PIC )术的100例冠心病患者，随机分为两组，各50例。观察组在PCI术前12 h及术前分别予以80 mg氟伐他汀口服，术后在常规治疗基础上每晚加服40 mg氟伐他汀长期治疗并联合康复护理干预；对照组术前给予安慰剂，术后予以常规治疗和护理），比较两组患者服药前、术后2 h、术后24 h外周血丙二醛（MDA）、活性氧簇（ROS）、一氧化氮（NO）等氧化应激因子水平以及随访半年后生活质量、再入院率、发生不良心血管事件几率的差异。结果两组服药前MDA，ROS，NO等氧化应激因子水平比较差异无统计学意义（ P>0.05），术后2 h、术后24 h两组患者外周血MDA，ROS，NO水平比较差异显著（ P<0.05）。随访半年后，观察组患者再入院率、心血管事件发生率明显低于对照组（ P<0.05），生活质量明显高于对照组（ P<0.05）。结论早期服用氟伐他汀可明显改善冠心病PCI术后氧化应激反应。术后氟伐他汀长期治疗联合康复护理干预可明显降低不良心血管事件发生率，改善预后。
目的：觀察氟伐他汀聯閤康複護理榦預對冠狀動脈粥樣硬化性心髒病（簡稱冠心病）介入治療患者氧化應激及再髮心血管事件的影響。方法抽選擇期首次行冠狀動脈介入( PIC )術的100例冠心病患者，隨機分為兩組，各50例。觀察組在PCI術前12 h及術前分彆予以80 mg氟伐他汀口服，術後在常規治療基礎上每晚加服40 mg氟伐他汀長期治療併聯閤康複護理榦預；對照組術前給予安慰劑，術後予以常規治療和護理），比較兩組患者服藥前、術後2 h、術後24 h外週血丙二醛（MDA）、活性氧簇（ROS）、一氧化氮（NO）等氧化應激因子水平以及隨訪半年後生活質量、再入院率、髮生不良心血管事件幾率的差異。結果兩組服藥前MDA，ROS，NO等氧化應激因子水平比較差異無統計學意義（ P>0.05），術後2 h、術後24 h兩組患者外週血MDA，ROS，NO水平比較差異顯著（ P<0.05）。隨訪半年後，觀察組患者再入院率、心血管事件髮生率明顯低于對照組（ P<0.05），生活質量明顯高于對照組（ P<0.05）。結論早期服用氟伐他汀可明顯改善冠心病PCI術後氧化應激反應。術後氟伐他汀長期治療聯閤康複護理榦預可明顯降低不良心血管事件髮生率，改善預後。
목적：관찰불벌타정연합강복호리간예대관상동맥죽양경화성심장병（간칭관심병）개입치료환자양화응격급재발심혈관사건적영향。방법추선택기수차행관상동맥개입( PIC )술적100례관심병환자，수궤분위량조，각50례。관찰조재PCI술전12 h급술전분별여이80 mg불벌타정구복，술후재상규치료기출상매만가복40 mg불벌타정장기치료병연합강복호리간예；대조조술전급여안위제，술후여이상규치료화호리），비교량조환자복약전、술후2 h、술후24 h외주혈병이철（MDA）、활성양족（ROS）、일양화담（NO）등양화응격인자수평이급수방반년후생활질량、재입원솔、발생불양심혈관사건궤솔적차이。결과량조복약전MDA，ROS，NO등양화응격인자수평비교차이무통계학의의（ P>0.05），술후2 h、술후24 h량조환자외주혈MDA，ROS，NO수평비교차이현저（ P<0.05）。수방반년후，관찰조환자재입원솔、심혈관사건발생솔명현저우대조조（ P<0.05），생활질량명현고우대조조（ P<0.05）。결론조기복용불벌타정가명현개선관심병PCI술후양화응격반응。술후불벌타정장기치료연합강복호리간예가명현강저불양심혈관사건발생솔，개선예후。
Objective To investigate the influence of fluvastatin combined with the rehabilitation nursing intervention on the oxidative stress and the recurrent cardiovascular events in the patients with interventional therapy of coronary heart disease ( CHD ) . Methods 100 cases of CHD undergoing elective first-time percutaneous coronary intervention ( PCI ) therapy were selected and randomly divided into two groups. The observation group ( n=50 ) was given oral fluvastatin 80 mg and 60 mg at 12 h before PCI and instantly before PCI re-spectively, on the basis of the conventional treatment 40 mg fluvastatin was postoperatively added at night for the long term therapy and combined with the rehabilitation nursing intervention. The control group ( n=50 ) was given placebo before PCI and the conventional therapy and nursing care. The levels of peripheral blood oxidative stress factors ( MDA, ROS, NO ) before medication, at postoperative 2 h, 24 h and the quality of life, re-admission rate and adverse cardiovascular event probability after 6-month follow up were compared be-tween the two groups. Results The levels of oxidative stress factors of MDA, ROS, NO before medication had no statistically significant differences between the two groups ( P>0. 05 );peripheral blood MDA, ROS, NO levels at postoperative 2 h, 24 h had statistically signifi-cant differences between the two groups ( P< 0. 05 ) . The re-admission rate and the occurrence rate of cardiovascular events after 6-month follow-up in the observation group was significantly lower than those in the control group ( P<0. 05 );while the quality of life in the observation group was obviously higher than that in the control group ( P<0. 05 ) . Conclusion Early administration of fluvastatin can significantly improve the oxidative stress response after PCI in CHD, the postoperative fluvastatin long term therapy combined with the rehabilitation nursing intervention can significantly reduce the incidence of adverse cardiovascular events and improve the prognosis.
