CAJ | 학술논문

目的：探讨慢性失眠患者汉字任务下脑激活区改变。方法对40例慢性失眠患者和50例正常对照组进行汉字工作记忆功能磁共振扫描。结果慢性失眠组与正常组脑激活区存在差异：慢性失眠组编码期枕叶、右前额和右边缘叶激活增强；保持期左前额激活下降；提取期激活增强区为右枕叶，激活下降区为左尾状核和右侧丘脑。结论慢性失眠患者在文字记忆任务编码期及提取期均出现了右脑皮层的代偿激活，保持期出现了左前额激活下降，提取期出现了皮层下区域激活的下降，提示慢性失眠在文字记忆处理过程出现了相关脑区的损害和异常激活。
목적：탐토만성실면환자한자임무하뇌격활구개변。방법대40례만성실면환자화50례정상대조조진행한자공작기억공능자공진소묘。결과만성실면조여정상조뇌격활구존재차이：만성실면조편마기침협、우전액화우변연협격활증강；보지기좌전액격활하강；제취기격활증강구위우침협，격활하강구위좌미상핵화우측구뇌。결론만성실면환자재문자기억임무편마기급제취기균출현료우뇌피층적대상격활，보지기출현료좌전액격활하강，제취기출현료피층하구역격활적하강，제시만성실면재문자기억처리과정출현료상관뇌구적손해화이상격활。
Objective To study the change in the brain activation area during the Chinese characters working memory task by functional magnetic resonance imaging (fMRI) in patients with chronic insomnia. Methods Forty chronic insomniacs and 50 good sleepers underwent fMRI while performing the Chinese characters working memory task by using block design, then compared the difference of accuracy and reaction time between the experimental and control group, as well as the degree of brain activation in the Chinese characters working coding, maintaining and extract processes. Results Chronic insomnia showed a longer response time and inaccuracy in the task (P=0.043, P=0.047). There are difference between chronic insomnia group and control group in brain activation area:occipital lobe, right frontal lobe and right limbic lobe showed increased activation in the coding process, while left frontal lobe showed declined activation in maintaining process. In extract process, right occipital lobe showed increased activation while declined activation in left caudate nucleus and right thalamus. Conclusion There are compensatory activations in the right cortex during coding and extract process while choric insomnia undergoing the Chinese characters working task. Left frontal lobe activation declines in maintaining process. Subcortical activation declines in extract process. It suggests that abnormal activation and damage occur in processes of the Chinese characters working task with choric insomnia.