CAJ | 학술논문

以克伦特罗、莱克多巴胺、沙丁胺醇为代表，阐明了β－受体激动剂在正离子软电离模式下的裂解机理。采用AB SCIEX 5500 QTRAP 三重四级杆电喷雾质谱仪，运用IDA－EPI技术，对β－受体激动剂类化合物裂解规律进行研究解析。结果表明，在ESI正电离模式下β－受体激动剂容易获得H＋而形成[M＋H]＋准分子离子峰，该结构易丢失水分子（H2O），继而与氨基结构相连的碳氮键（－C－N－）发生断裂，形成与苯环共轭的（ Ph－CH＝CH－NH＋－）离子结构。本研究为同类化合物的结构解析提供了可靠依据以及跟踪新型β－受体激动剂提供了有力手段。
이극륜특라、래극다파알、사정알순위대표，천명료β－수체격동제재정리자연전리모식하적렬해궤리。채용AB SCIEX 5500 QTRAP 삼중사급간전분무질보의，운용IDA－EPI기술，대β－수체격동제류화합물렬해규률진행연구해석。결과표명，재ESI정전리모식하β－수체격동제용역획득H＋이형성[M＋H]＋준분자리자봉，해결구역주실수분자（H2O），계이여안기결구상련적탄담건（－C－N－）발생단렬，형성여분배공액적（ Ph－CH＝CH－NH＋－）리자결구。본연구위동류화합물적결구해석제공료가고의거이급근종신형β－수체격동제제공료유력수단。
To clarify pyrolysis mechanism of β-receptor agonists under positive mode, representative drugs including clenbuterol, salbutamol and ractopamine had been chosen to study with AB SCIEX 5500 QTRAP triple quadrupole mass spectrometry and IDA-EPI technology. The results showed that under ESI positive mode, β-receptor agonists were easy to form [ M+H]+. The structure was easy to loss neutral molecules, such as H2 O. Moreover, the C-N bond connected with amino group was easy to broken and produce conjugated ion structure with benzene. This study had important theory research significance and practical value, such as providing reliable basis for otherβ-receptor agonists structural analysis and providing powerful means to track newβ-receptor agonists.