CAJ | 학술논문

为了探究灵芝活性组分灵芝多肽、多糖的降血糖机理，采用四氧嘧啶建立糖尿病小鼠模型，经不同组分灵芝提取物灌胃连续4周后测定空腹血糖值、胰岛素浓度、肝糖原、肌糖原含量、肝脏SOD活性MDA含量。结果表明，灵芝多糖能有效增加小鼠血清胰岛素浓度（ P＜0．05）；灵芝多肽和多糖可显著降低糖尿病小鼠空腹血糖含量，降糖率分别为19．1％和29．8％；显著增强小鼠肝脏SOD活性（P＜0．05），升高率分别为13．4％和19．7％；降低肝脏MDA含量（P＜0．05），且分别降低了27．8％和35．1％。
위료탐구령지활성조분령지다태、다당적강혈당궤리，채용사양밀정건립당뇨병소서모형，경불동조분령지제취물관위련속4주후측정공복혈당치、이도소농도、간당원、기당원함량、간장SOD활성MDA함량。결과표명，령지다당능유효증가소서혈청이도소농도（ P＜0．05）；령지다태화다당가현저강저당뇨병소서공복혈당함량，강당솔분별위19．1％화29．8％；현저증강소서간장SOD활성（P＜0．05），승고솔분별위13．4％화19．7％；강저간장MDA함량（P＜0．05），차분별강저료27．8％화35．1％。
Test is designed to explore the mechanism of Ganoderma lucidum hypoglycemic active components, Ganoderma lucidum peptides and polysaccharide. The diabetic mice model was established by using alloxan. The diabetic mice were orally given with different Ganoderma lucidum extracts for four weeks. The fasting blood glucose ( FBG) concentrations, insulin concentrations, content of liver glycogen and muscle glycogen, hepatic SOD and MDA level were measured. The results showed that Ganoderma lucidum polysaccharide significantly increased the insulin concentrations of the diabetic mice ( P <0. 05 ) . Ganoderma lucidum peptides and polysaccharide all significantly decreased the FBG of diabetic mice by 19.1%and 29.8%, respectively ( P<0.05) . Improved the activity of hepatic SOD by 13.4%, 19.7%, respectively ( P<0.05) . Decreased the level of hepatic MDA significantly by 27.8%, 35.1%, respectively ( P<0.05) .