CAJ | 학술논문

缺血性卒中后的病理生理反应很复杂，单纯注重挽救神经元在临床研究中并不能有效达到神经保护作用。神经血管单位中的“血管龛”假说强调神经再生和血管再生之间复杂的相互作用，从而有效修复脑缺血损伤。本综述中主要简述了运动锻炼对缺血性卒中的保护和治疗作用，运动疗法的保护机制包括增加脑灌注、促进神经再生、侧支循环、血管再生等。本综述旨在认识血管再生的重要性，可望其成为缺血性卒中治疗的新途径。
결혈성졸중후적병리생리반응흔복잡，단순주중만구신경원재림상연구중병불능유효체도신경보호작용。신경혈관단위중적“혈관감”가설강조신경재생화혈관재생지간복잡적상호작용，종이유효수복뇌결혈손상。본종술중주요간술료운동단련대결혈성졸중적보호화치료작용，운동요법적보호궤제포괄증가뇌관주、촉진신경재생、측지순배、혈관재생등。본종술지재인식혈관재생적중요성，가망기성위결혈성졸중치료적신도경。
Pathophysiologic responses in brain after stroke are highly complex. Thus far, a singular focus on saving neurons alone has not revealed any clinically effective neuroprotection. To address this limitation, the concept of a neurovascular unit was developed. The vascular niche hypothesis highlights the complex interactions of neuro- and angiogenesis for regenerative and repair mechanisms in the human brain. In this review, we briefly describe the protective and therapeutic effects of exercise on stroke. The protective mechanisms induced by exercise include increased perfusion as well as mechanisms of neurogenesis, collateral recruitment and angiogenesis. The purpose of this review is to evaluate the evidence that angiogenesis is a target for recovery after an ischemic stroke.