CAJ | 학술논문

目的：了解急性丘脑卒中伴嗜睡患者血浆中下丘脑分泌素（hypocretin，Hcrt）及白细胞介素-17（interleukin 17，IL-17）的变化，探索丘脑卒中炎性反应的发生机制。方法选择2013年3月～2014年3月在天津医科大学总医院神经内科住院的经头颅影像学检查证实的急性丘脑卒中的患者34例为研究对象，按有无嗜睡的发生将其分为丘脑卒中伴嗜睡组（18例）和丘脑卒中不伴嗜睡组（16例），检测两组患者血浆中Hcrt、IL-17水平的差异，观察比较急性期丘脑卒中睡眠障碍血浆中Hcrt和炎性因子的改变。结果丘脑卒中伴嗜睡组Hcrt水平较不伴嗜睡组增高，P=0.001。丘脑卒中伴嗜睡组IL-17水平较不伴嗜睡组增高，P=0.001。结论 Hcrt可能是丘脑卒中后睡眠-觉醒障碍的一个敏感的生化指标，IL-17可能参与了急性丘脑卒中睡眠障碍炎性病理机制的发生过程。
목적：료해급성구뇌졸중반기수환자혈장중하구뇌분비소（hypocretin，Hcrt）급백세포개소-17（interleukin 17，IL-17）적변화，탐색구뇌졸중염성반응적발생궤제。방법선택2013년3월～2014년3월재천진의과대학총의원신경내과주원적경두로영상학검사증실적급성구뇌졸중적환자34례위연구대상，안유무기수적발생장기분위구뇌졸중반기수조（18례）화구뇌졸중불반기수조（16례），검측량조환자혈장중Hcrt、IL-17수평적차이，관찰비교급성기구뇌졸중수면장애혈장중Hcrt화염성인자적개변。결과구뇌졸중반기수조Hcrt수평교불반기수조증고，P=0.001。구뇌졸중반기수조IL-17수평교불반기수조증고，P=0.001。결론 Hcrt가능시구뇌졸중후수면-각성장애적일개민감적생화지표，IL-17가능삼여료급성구뇌졸중수면장애염성병리궤제적발생과정。
Objective To evaluate the changes of hypocretin and interleukin 17 (IL-17) in serum and to examine the mechanism underlying inlfammatory reaction of acute thalamic stroke. Methods We measured the level of hypocretin and IL-17 in the serum of 34 patients who suffered acute stroke during Tianjin Medical University General Hospital between March 2013 and March 2014. The patients can be divided into two groups according to with or without somnolence. Results Compared with thalamic stroke without somnolence group, the level of hypocretin in thalamic stroke with somnolence was higher (P=0.001). Signiifcant differences were also found in the level of IL-17. The level of IL-17 was higher in thalamic stroke with somnolence group than in thalamic stroke without somnolence group (P=0.001). Conclusion The level of hypoctetin may be a sensitive biochemical for sleep disorder after thalamic stroke, suggesting that IL-17 may participate in the pathogenesis of the inflammatory process in acute thalamic stroke patients with sleep disorders.