中国医疗器械信息
中國醫療器械信息
중국의료기계신식
CHINA MEDICAL DEVICES INFORMATION
2015年
1期
59-61
,共3页
谢新艺%方旻%黄梓为
謝新藝%方旻%黃梓為
사신예%방민%황재위
输液器%抗氧剂1010%抗氧剂168%紫杉醇注射液
輸液器%抗氧劑1010%抗氧劑168%紫杉醇註射液
수액기%항양제1010%항양제168%자삼순주사액
infusion sets%irgafos 168%irganox 1010%paclitaxel injection
本文建立了液相色谱法测定输液器中四-[β-(3,5-二叔丁基-4-羟基苯基)丙酸]季戊四醇酯(抗氧剂1010)和亚磷酸三(2,4-二叔丁基苯基)酯(抗氧剂168)在紫杉醇注射液中的溶出情况,结果表明:两种抗氧剂的检测限依次为0.38μ g/m l和1.58μ g/m l,在3个浓度水平上对方法做回收试验,测得回收率为109.9%和81.0%。该方法简便、快速、准确,适用于紫杉醇注射液中抗氧剂1010和抗氧剂168的检测。
本文建立瞭液相色譜法測定輸液器中四-[β-(3,5-二叔丁基-4-羥基苯基)丙痠]季戊四醇酯(抗氧劑1010)和亞燐痠三(2,4-二叔丁基苯基)酯(抗氧劑168)在紫杉醇註射液中的溶齣情況,結果錶明:兩種抗氧劑的檢測限依次為0.38μ g/m l和1.58μ g/m l,在3箇濃度水平上對方法做迴收試驗,測得迴收率為109.9%和81.0%。該方法簡便、快速、準確,適用于紫杉醇註射液中抗氧劑1010和抗氧劑168的檢測。
본문건립료액상색보법측정수액기중사-[β-(3,5-이숙정기-4-간기분기)병산]계무사순지(항양제1010)화아린산삼(2,4-이숙정기분기)지(항양제168)재자삼순주사액중적용출정황,결과표명:량충항양제적검측한의차위0.38μ g/m l화1.58μ g/m l,재3개농도수평상대방법주회수시험,측득회수솔위109.9%화81.0%。해방법간편、쾌속、준학,괄용우자삼순주사액중항양제1010화항양제168적검측。
To develop the high performance liquid chromatography (HPLC) method for investigation of the dissolution of Irgafos 168 and Irganox 1010 in paclitaxel injection. Detection limits found for Irganox 1010 and Irgafos 168 were 0.38μg/ml and 1.58μg/ml. Recovery tested at 3 concentration levels were 109.9% and 81.0%.The method was simple, efifcient and accurate and suitable for analysis of Irgafos 168 and Irganox 1010 in paclitaxel injection.