中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
24期
27-28,29
,共3页
多索茶碱%布地奈德%哮喘急性发作%γ-干扰素%白细胞介素-4
多索茶堿%佈地奈德%哮喘急性髮作%γ-榦擾素%白細胞介素-4
다색다감%포지내덕%효천급성발작%γ-간우소%백세포개소-4
doxofylline%budesonide%acute attack of asthma%IFN-γ%IL-4
目的：探讨多索茶碱注射联合布地奈德雾化吸入治疗支气管哮喘急性发作的临床疗效及对细胞因子γ干扰素（IFN－γ）和白细胞介素－4（IL－4）水平的影响。方法选取2012年1月至2013年10月医院收治的支气管哮喘急性发作患者168例，随机分为对照组82例和观察组86例。两组患者均采用基础治疗加布地奈德雾化吸入，对照组加用氨茶碱静脉滴注，观察组加用多索茶碱静脉滴注。观察两组患者的临床疗效、主要症状和体征改善情况，于治疗前后测定气道阻力、外周血IFN－γ和IL－4的水平。结果观察组的总有效率为89.53%，明显高于对照组的74.39%（ P﹤0.05）；两组患者咳嗽、喘息和肺内哮鸣音评分治疗后均较治疗前下降，且观察组下降更显著（ P﹤0.05）；两组患者治疗后气道阻力均明显减少，且观察组减少较对照组更显著（ P﹤0.05）；两组患者细胞因子水平治疗后均较治疗前改善，且观察组改善幅度更大（ P﹤0.05）。治疗过程中，观察组不良反应发生率为9.30%，明显低于对照组的24.39%（ P﹤0.05）。结论多索茶碱注射联合布地奈德雾化吸入治疗支气管哮喘急性发作的临床疗效好，能显著改善症状，且不良反应少，并可通过调节血清IFN－γ和IL－4水平调节免疫功能，值得推广。
目的：探討多索茶堿註射聯閤佈地奈德霧化吸入治療支氣管哮喘急性髮作的臨床療效及對細胞因子γ榦擾素（IFN－γ）和白細胞介素－4（IL－4）水平的影響。方法選取2012年1月至2013年10月醫院收治的支氣管哮喘急性髮作患者168例，隨機分為對照組82例和觀察組86例。兩組患者均採用基礎治療加佈地奈德霧化吸入，對照組加用氨茶堿靜脈滴註，觀察組加用多索茶堿靜脈滴註。觀察兩組患者的臨床療效、主要癥狀和體徵改善情況，于治療前後測定氣道阻力、外週血IFN－γ和IL－4的水平。結果觀察組的總有效率為89.53%，明顯高于對照組的74.39%（ P﹤0.05）；兩組患者咳嗽、喘息和肺內哮鳴音評分治療後均較治療前下降，且觀察組下降更顯著（ P﹤0.05）；兩組患者治療後氣道阻力均明顯減少，且觀察組減少較對照組更顯著（ P﹤0.05）；兩組患者細胞因子水平治療後均較治療前改善，且觀察組改善幅度更大（ P﹤0.05）。治療過程中，觀察組不良反應髮生率為9.30%，明顯低于對照組的24.39%（ P﹤0.05）。結論多索茶堿註射聯閤佈地奈德霧化吸入治療支氣管哮喘急性髮作的臨床療效好，能顯著改善癥狀，且不良反應少，併可通過調節血清IFN－γ和IL－4水平調節免疫功能，值得推廣。
목적：탐토다색다감주사연합포지내덕무화흡입치료지기관효천급성발작적림상료효급대세포인자γ간우소（IFN－γ）화백세포개소－4（IL－4）수평적영향。방법선취2012년1월지2013년10월의원수치적지기관효천급성발작환자168례，수궤분위대조조82례화관찰조86례。량조환자균채용기출치료가포지내덕무화흡입，대조조가용안다감정맥적주，관찰조가용다색다감정맥적주。관찰량조환자적림상료효、주요증상화체정개선정황，우치료전후측정기도조력、외주혈IFN－γ화IL－4적수평。결과관찰조적총유효솔위89.53%，명현고우대조조적74.39%（ P﹤0.05）；량조환자해수、천식화폐내효명음평분치료후균교치료전하강，차관찰조하강경현저（ P﹤0.05）；량조환자치료후기도조력균명현감소，차관찰조감소교대조조경현저（ P﹤0.05）；량조환자세포인자수평치료후균교치료전개선，차관찰조개선폭도경대（ P﹤0.05）。치료과정중，관찰조불량반응발생솔위9.30%，명현저우대조조적24.39%（ P﹤0.05）。결론다색다감주사연합포지내덕무화흡입치료지기관효천급성발작적림상료효호，능현저개선증상，차불량반응소，병가통과조절혈청IFN－γ화IL－4수평조절면역공능，치득추엄。
Objective To investigate the clinical efficacy of doxofylline combined with budesonide atomization inhalation for treating acute attack of bronchial asthma and its effect on the cytokine IFN-γ and IL-4 levels. Methods 168 patients with acute attack of bronchial asthma in the hospital from January 2012 to October 2013 were selected and randomly divided into the control group(82 cas-es) and the observation group(86 cases). The two group all adopted the basic therapy plus budesonide atomization inhalation. On this basis,the control group was added with aminophyline by intravenous drip,while the observation group was given doxofylline by intra-venous drip. The clinical efficacy and improvement of the main symptoms and signs were observed,the airway resistance,peripheral blood IFN-γ and IL-4 levels were detected before and after treatment. Results The total effective rate of the observation group was 89. 53%,which was significantty higher than 74. 39% in the control group( P ﹤ 0. 05);the cough,wheezing and lung wheeze scores af-ter treatment in the two groups were significantly decreased compared with before treatment( P ﹤ 0. 05);the airway resistance after treatment in the two groups was significantly decreased,but the decrease in the observation group was more significant than that in the control group,the difference was statistically significant( P ﹤ 0. 05);the cytokines levels after treatment were improved in the two groups,but which in the observation group were greatly improved( P ﹤ 0. 05). The occurrence rate of adverse reactions was 9. 30% in the observation group,which was significantly lower than 24. 39% in the control( P ﹤ 0. 05). Conclusion Doxofylline injection com-bined with budesonide atomization inhalation has better clinical effect for treating acute attack of bronchial asthma,can significantly im-prove the symptoms,has less adverse reactions,can regulate the immune function by regulating the serum IFN-γ and IL-4 levels, which is worthy of clinical promotcon.
