CAJ | 학술논문

目的：探讨中药内服外敷对膝骨性关节炎（KOA）患者血清白细胞介素－1( IL－1)及肿瘤坏死因子－α( TNF－α)水平的影响。方法观察并记录168例KOA患者在服用滋补肝肾活血通络方及外敷膝痛外敷方治疗前、治疗后3 d、1周、2周、4周血清IL－1、TNF－α水平及疼痛视觉模拟评分（VAS）。结果 KOA患者VAS、IL－1及TNF－α在治疗后3 d较治疗前下降不明显，在治疗后1周较治疗前显著下降（ P﹤0.05），治疗后2周及4周时下降更显著（ P﹤0.01）。结论中药内服外敷可缓解KOA患者疼痛，且能降低血清IL－1及TNF－α水平，适合KOA患者的长期治疗。
목적：탐토중약내복외부대슬골성관절염（KOA）환자혈청백세포개소－1( IL－1)급종류배사인자－α( TNF－α)수평적영향。방법관찰병기록168례KOA환자재복용자보간신활혈통락방급외부슬통외부방치료전、치료후3 d、1주、2주、4주혈청IL－1、TNF－α수평급동통시각모의평분（VAS）。결과 KOA환자VAS、IL－1급TNF－α재치료후3 d교치료전하강불명현，재치료후1주교치료전현저하강（ P﹤0.05），치료후2주급4주시하강경현저（ P﹤0.01）。결론중약내복외부가완해KOA환자동통，차능강저혈청IL－1급TNF－α수평，괄합KOA환자적장기치료。
Objective To explore the effects of oral and external application of traditional Chinese medicines on the serum levels of IL-1 and TNF-α in the patients with knee osteoarthritis(KOA). Methods The Visual Analogue Scale(VAS)scores and serum levels of IL-1 and TNF-α were observed in 168 patients with KOA before the treatment of oral prescription for nourishing liver and kid-ney,and promoting blood circulation to remove meridian obstruction,and the external application of the gonalgia external application pre-scription and on 3 d,at 1,2,4 weeks after treatment. Results The VAS scores and serum levels of IL-1 and TNF-α on 3 d after treatment did not decreased obviously,but which were significantly decreased after 1-week treatment( P ﹤ 0. 05)and more significantly decreased after 2-week and 4-week treatment( P ﹤ 0. 01). Conclusion Oral and external application of traditional Chinese medicines relieves the pain of KOA and simultaneously decreases the serum levels of IL-1 and TNF-α,which is suitable for the long term treatment of the KOA patients.