CAJ | 학술논문

目的：探讨胎盘多肽联合抗结核药物应用于肺结核活动期的临床疗效及联合用药后的不良反应发生率。方法将本院180例初治痰菌阳性、且胸片上有斑片阴影或是结核空洞，或是播散病灶的患者分成两组。治疗组90例，在给予常规抗结核药物基础上给予胎盘多肽注射液，4 ml/日；对照组90例，给予常规抗结核药物治疗90例。结果治疗后治疗组和对照组的结核杆菌转阴率为97.8%和76.6%（P＜0.01），病灶吸收好转率为97.8%和77.7%（P＜0.01），治疗二个月后症状缓解率为95.6%和30.3%（P＜0.001）。肝损害发生率为5.6%和30.0%（P＜0.001），皮疹发生率为3.3%和13.3%（P＜0.05）。两种治疗方法疗效对比具有统计学差异。结论肺结核活动期使用胎盘多胎注射液联合抗结核药物加速痰涂转阴，更加快速地改善症状、缩短抗结核疗程并减少不良反应的发生，从而增加患者的依从性、减少肺结核的复发和耐药的发生。
목적：탐토태반다태연합항결핵약물응용우폐결핵활동기적림상료효급연합용약후적불량반응발생솔。방법장본원180례초치담균양성、차흉편상유반편음영혹시결핵공동，혹시파산병조적환자분성량조。치료조90례，재급여상규항결핵약물기출상급여태반다태주사액，4 ml/일；대조조90례，급여상규항결핵약물치료90례。결과치료후치료조화대조조적결핵간균전음솔위97.8%화76.6%（P＜0.01），병조흡수호전솔위97.8%화77.7%（P＜0.01），치료이개월후증상완해솔위95.6%화30.3%（P＜0.001）。간손해발생솔위5.6%화30.0%（P＜0.001），피진발생솔위3.3%화13.3%（P＜0.05）。량충치료방법료효대비구유통계학차이。결론폐결핵활동기사용태반다태주사액연합항결핵약물가속담도전음，경가쾌속지개선증상、축단항결핵료정병감소불량반응적발생，종이증가환자적의종성、감소폐결핵적복발화내약적발생。
Objection To investigate the curative effect and the incidence of adverse reaction of piacenta polypeptide injection combined with ani-tuberculosis drug on the treatment of active pulmonary tuberculosis. Method Atotal of 180 sputum positive patients with patchy opacities shadow in chest radiograph or lesions dissemination were equally and randomly divided into single-agent and combined groups.Patients in combined group received anti-tuberculosis drug in combination with placenta polypeptide injection 4ml/day.Those in single-agent group only received anti-tuberculosis.Results After treatment,the sputum negative conversion rate of treatment and control group were 97.8% and 76.6% separately(P<0.01).Focuts absorpticn rates were 97.8% and 76.6% separately(P<0.01).The symptoms remission rates were 95.6% and 30.3% separately(P<0.001),The incidences of liver damage were 5.6% and 30.0% separately(P<0.001).The incidences of rash were 3.3% and 13.3% separately(P<0.05).