CAJ | 학술논문

目的：观察辅酶Q10对糖尿病合并左心室舒张功能障碍患者的改善及其机制。方法：将本院收治的106例2型糖尿病患者分为对照组(常规治疗,n＝53)和治疗组(在常规治疗基础上予辅酶Q1010 mg,每天3次,疗程为6个月,n＝53)。治疗前后检查心功能测定,包括射血分数、舒张功能指标等。结果：对照组治疗6个月后,舒张早期和舒张晚期峰流速分别为(59±28) cm/s和(81±23) cm/s,与治疗前比较,差异无统计学意义(P>0.05)；治疗组治疗6个月后,舒张早期和舒张晚期峰流速分别为(69±21) cm/s和(66±22) cm/s,与治疗前比较,差异有统计学意义(P<0.05)。治疗组治疗6个月后,血清氧化应激指标( SOD、MDA)和炎症指标( hs-CRP、IL-6)较治疗前明显改善( P<0.05),而对照组上述指标改善不大( P>0.05)。结论：辅酶Q10可以改善2型糖尿病早期左心室舒张功能障碍,其机制可能与调控氧化应激和炎症反应有关。
목적：관찰보매Q10대당뇨병합병좌심실서장공능장애환자적개선급기궤제。방법：장본원수치적106례2형당뇨병환자분위대조조(상규치료,n＝53)화치료조(재상규치료기출상여보매Q1010 mg,매천3차,료정위6개월,n＝53)。치료전후검사심공능측정,포괄사혈분수、서장공능지표등。결과：대조조치료6개월후,서장조기화서장만기봉류속분별위(59±28) cm/s화(81±23) cm/s,여치료전비교,차이무통계학의의(P>0.05)；치료조치료6개월후,서장조기화서장만기봉류속분별위(69±21) cm/s화(66±22) cm/s,여치료전비교,차이유통계학의의(P<0.05)。치료조치료6개월후,혈청양화응격지표( SOD、MDA)화염증지표( hs-CRP、IL-6)교치료전명현개선( P<0.05),이대조조상술지표개선불대( P>0.05)。결론：보매Q10가이개선2형당뇨병조기좌심실서장공능장애,기궤제가능여조공양화응격화염증반응유관。
Objective:To observe the effect and mechanism of coenzyme Q10 in type 2 diabetic patients with left ventricular diastolic dysfunction. Methods:106 type 2 diabetic patients were divided into the control group (conventional therapy, n=53) and the treatment group (10 mg coenzyme Q10 on the basis of conventional therapy, 3 times/day, 6 months for a course of treatment, n=53) . Before and after treatment, cardiac function was measured, including ejection fraction, diastolic function indexes, etc.Results: After six months treatment of the control group, the peak expiratory flow rate of early diastole phase and late diastole phase were (59±28) cm/s and(81±23) cm/s respectively, which had no statistical significance compared to those before the treatment (P>0.05) . After six months treatment of the treatment group, the peak expiratory flow rate of early diastole phase and late diastole phase were (69±21) cm/s and (66±22) cm/s respectively, which had statistical significance compared to those before the treatment ( P<0.05) . The change of oxidative stress and inflammation index levels of both groups after 6 months treatment could be seen in table 2. After 6 months treatment, serum oxidative stress indicators (SOD, MDA) and inflammation indicators ( hs-CRP, IL-6) were significantly improved in the treatment group compared to those before the treatment ( P<0.05) , which had no significant improvement in the control group (P>0.05).Conclusion: Coenzyme Q10 can improve early left ventricular diastolic dysfunction in type 2 diabetic patients, and its mechanism may be related to regulation of oxidative stress and inflammation response.