广州医科大学学报
廣州醫科大學學報
엄주의과대학학보
Academic Journal of Guangzhou Medical College
2014年
4期
35-37
,共3页
古丽努尔·伊斯拉木%李应琴
古麗努爾·伊斯拉木%李應琴
고려노이·이사랍목%리응금
2型糖尿病%骨质疏松症%C肽%骨钙素
2型糖尿病%骨質疏鬆癥%C肽%骨鈣素
2형당뇨병%골질소송증%C태%골개소
type 2 diabetes%osteoporosis%proinsulin C-peptide%bone gla protein
目的：检测2型糖尿病合并骨质疏松症患者血清C肽及骨钙素( BGP )水平。方法：收集2013年2月至2014年1月本院老年病科住院治疗的2型糖尿病患者96例，按骨质疏松症诊断标准分为2型糖尿病合并骨质疏松症组( A组)和单纯2型糖尿病组( B组)。测定两组患者大转子、股骨颈、Wards区的骨密度，比较两组患者的血清甘油三酯( TG)、空腹血糖( FBG)、总胆固醇( TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、餐后2 h血糖(P2hBG)、空腹C肽、餐后2 h C肽及BGP水平。结果：两组患者血清TG、FBG等生化指标差异均无统计学意义(均P>0.05)。 A组患者大转子、股骨颈及Wards区骨密度均显著低于B组(均P<0.05)。 A组患者血清空腹C肽、餐后2 h C肽及BGP水平显著低于B组(均P<0.05)。结论：血清C肽及BGP可作为2型糖尿病合并骨质疏松症患者筛查的潜在指标。
目的：檢測2型糖尿病閤併骨質疏鬆癥患者血清C肽及骨鈣素( BGP )水平。方法：收集2013年2月至2014年1月本院老年病科住院治療的2型糖尿病患者96例，按骨質疏鬆癥診斷標準分為2型糖尿病閤併骨質疏鬆癥組( A組)和單純2型糖尿病組( B組)。測定兩組患者大轉子、股骨頸、Wards區的骨密度，比較兩組患者的血清甘油三酯( TG)、空腹血糖( FBG)、總膽固醇( TC)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、餐後2 h血糖(P2hBG)、空腹C肽、餐後2 h C肽及BGP水平。結果：兩組患者血清TG、FBG等生化指標差異均無統計學意義(均P>0.05)。 A組患者大轉子、股骨頸及Wards區骨密度均顯著低于B組(均P<0.05)。 A組患者血清空腹C肽、餐後2 h C肽及BGP水平顯著低于B組(均P<0.05)。結論：血清C肽及BGP可作為2型糖尿病閤併骨質疏鬆癥患者篩查的潛在指標。
목적：검측2형당뇨병합병골질소송증환자혈청C태급골개소( BGP )수평。방법：수집2013년2월지2014년1월본원노년병과주원치료적2형당뇨병환자96례，안골질소송증진단표준분위2형당뇨병합병골질소송증조( A조)화단순2형당뇨병조( B조)。측정량조환자대전자、고골경、Wards구적골밀도，비교량조환자적혈청감유삼지( TG)、공복혈당( FBG)、총담고순( TC)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)、찬후2 h혈당(P2hBG)、공복C태、찬후2 h C태급BGP수평。결과：량조환자혈청TG、FBG등생화지표차이균무통계학의의(균P>0.05)。 A조환자대전자、고골경급Wards구골밀도균현저저우B조(균P<0.05)。 A조환자혈청공복C태、찬후2 h C태급BGP수평현저저우B조(균P<0.05)。결론：혈청C태급BGP가작위2형당뇨병합병골질소송증환자사사적잠재지표。
Objective:To detect the expression levels of the proinsulin C-peptide and Bone Gla Protein (BGP) in patients with type 2 diabetes mellitus complicated with osteoporosis.Methods:A total of 96 patients with type 2 diabetes mellitus admitted in the Department of Geriatrics of our hospital from February 2013 to January 2014, were divided into type 2 diabetes mellitus complicated with osteoporosis group ( observation group) and simple type 2 diabetes ( control group ) based on the diagnosis criteria of osteoporosis. Bone densities of greater trochanter, femoral neck and Wards area of the two groups were measured. And serum triglyceride ( TG) , fasting blood-glucose ( FBG ) , total cholesterol ( TC ) , low density lipoprotein- cholesterin ( LDL-C ) , high density lipoprotein-cholesterol ( HDL-C ) , postprandial 2h blood glucose ( P2hBG ) , fasting Proinsulin C-peptide, BGP and postprandial 2h Proinsulin C-peptide levels of the two groups were detected. Results: There was no stastical significance between the two groups on TG, FBG and biochemical indicators (P>0.05). Bone densities of greater trochanter, femoral neck and Wards area of the observation group were significantly lower than those of the control group (P<0.05). Fasting Proinsulin C-peptide, postprandial 2 h Proinsulin C-peptide and BGP were significantly lower than those of the control group ( P<0.05) . Conclusion:Serum proinsulin C-peptide and BGP can be used as potential index for the screening on patients with type 2 diabetes complicated with osteoporosis.
