广州医科大学学报
廣州醫科大學學報
엄주의과대학학보
Academic Journal of Guangzhou Medical College
2014年
4期
113-115
,共3页
羊水过少%丹参%肝素,低分子量%血液凝固试验
羊水過少%丹參%肝素,低分子量%血液凝固試驗
양수과소%단삼%간소,저분자량%혈액응고시험
oligohydramnios%salvia miltiorrhiza%heparin%low molecular weight%blood coagulation test
目的：观察低分子肝素联合静脉补液治疗羊水过少的疗效及安全性。方法：回顾性分析2008年3月至2011年10月本院收治的93例羊水过少患者的临床资料。48例治疗组患者应用低分子肝素联合静脉补液治疗；45例对照组患者应用丹参联合静脉补液治疗,7 d为1个疗程,比较两组治疗前后羊水指数( AFI)、相关凝血指标、剖宫产率、新生儿窒息率及产后出血量等指标。结果：治疗组未发生因使用肝素所致的产后出血、血肿、皮肤黏膜出血及过敏反应等。对照组和治疗组治疗后的AFI均较治疗前升高(P<0.05),其中治疗组治疗后AFI高于对照组(P<0.05)。两组患者治疗前后PLT、PT、APTT、TT和FIB比较,差异均无统计学意义(均P>0.05)。治疗组新生儿窒息率、剖宫产率均明显低于对照组( P<0.05)；两组产后出血量比较,差异无统计学意义( P>0.05)。结论：低分子肝素联合静脉补液是治疗妊娠晚期羊水过少安全、有效方法,可改善妊娠结局。
目的：觀察低分子肝素聯閤靜脈補液治療羊水過少的療效及安全性。方法：迴顧性分析2008年3月至2011年10月本院收治的93例羊水過少患者的臨床資料。48例治療組患者應用低分子肝素聯閤靜脈補液治療；45例對照組患者應用丹參聯閤靜脈補液治療,7 d為1箇療程,比較兩組治療前後羊水指數( AFI)、相關凝血指標、剖宮產率、新生兒窒息率及產後齣血量等指標。結果：治療組未髮生因使用肝素所緻的產後齣血、血腫、皮膚黏膜齣血及過敏反應等。對照組和治療組治療後的AFI均較治療前升高(P<0.05),其中治療組治療後AFI高于對照組(P<0.05)。兩組患者治療前後PLT、PT、APTT、TT和FIB比較,差異均無統計學意義(均P>0.05)。治療組新生兒窒息率、剖宮產率均明顯低于對照組( P<0.05)；兩組產後齣血量比較,差異無統計學意義( P>0.05)。結論：低分子肝素聯閤靜脈補液是治療妊娠晚期羊水過少安全、有效方法,可改善妊娠結跼。
목적：관찰저분자간소연합정맥보액치료양수과소적료효급안전성。방법：회고성분석2008년3월지2011년10월본원수치적93례양수과소환자적림상자료。48례치료조환자응용저분자간소연합정맥보액치료；45례대조조환자응용단삼연합정맥보액치료,7 d위1개료정,비교량조치료전후양수지수( AFI)、상관응혈지표、부궁산솔、신생인질식솔급산후출혈량등지표。결과：치료조미발생인사용간소소치적산후출혈、혈종、피부점막출혈급과민반응등。대조조화치료조치료후적AFI균교치료전승고(P<0.05),기중치료조치료후AFI고우대조조(P<0.05)。량조환자치료전후PLT、PT、APTT、TT화FIB비교,차이균무통계학의의(균P>0.05)。치료조신생인질식솔、부궁산솔균명현저우대조조( P<0.05)；량조산후출혈량비교,차이무통계학의의( P>0.05)。결론：저분자간소연합정맥보액시치료임신만기양수과소안전、유효방법,가개선임신결국。
Objective:To observe the efficacy and safety of low molecular weight heparin ( LMWP ) combined with intravenous rehydration on oligohydramnios. Methods: The clinical data of 93 patients with oligohydramnios admitted in our hospital from March 2008 to October 2011 were retrospectively analyzed. 48 patients in the treatment group were treated by low molecular weight heparin combined with intravenous rehydration; 45 patients in the control group were treated by salvia miltiorrhiza combined with intravenous rehydration, 7 days as 1 course. Amnionic fluid index (AFI), related coagulogram markers, percentages of cesarean section, neonatal asphyxia rate and postpartum hemorrhage volume, etc. were compared before and after treatment between the two groups. Results: In the treatment group, there was no postpartum hemorrhage, hematoma, mucocutaneous hemorrhage and anaphylactic reaction, etc caused by the using of heparin. After treatment, the average increasing volume of AFI in both of the control group and the treatment group increased than before treatment. And the AFI of the treatment was significantly higher than in control group (P<0.05). There was no statistical significance of PLT, PT, APTT, TT and FIB between before and after treatment of the two groups ( P>0.05) . The rates of neonatal asphyxia and caesarean section were significantly lower in treatment group than in control group ( P<0.05) . There was no significant difference in blood coagulation indication before and after treatment between the two groups ( P>0. 05 ) . Conclusion:LMWP combined with intravenous rehydration was a safe and effective method to treat oligoamnios of late trimester of pregnancy, and could improve pregnancy outcome.
