CAJ | 학술논문

目的：探讨经支气管镜二氧化碳（CO2）冷冻联合氩气刀治疗结核性大气道狭窄的临床疗效。方法选取2010年3月至2013年6月收治的结核性大气道狭窄患者150例，按患者住院顺序分为3个组，对照1组、对照2组和研究组。3个组患者均应用抗结核药物、雾化吸入、局部注药；对照1组：50例，给予氩气刀治疗；对照2组：50例，给予冷冻治疗；研究组：50例，则给予支气管镜介入冷冻联合氩气刀治疗。3个组总疗程6个月。并对3个组临床治疗效果进行对比分析。结果3个组患者的经治疗后，研究组的缓解率为94．0％，明显优于对照1组的70．0％和对照2组的64．0％，组间差异有统计学意义（ P＜0．05）。同时，研究组患者气管内径及 FEV1／FVC比值也较对照1组、对照2组明显改善，差异有统计学意义（P＜0．05）。结论经支气管镜冷冻联合氩气刀进行结核性大气道狭窄治疗具有较好的临床治疗效果，同时安全性高，无严重并发症，具有较高的临床推广价值。
목적：탐토경지기관경이양화탄（CO2）냉동연합아기도치료결핵성대기도협착적림상료효。방법선취2010년3월지2013년6월수치적결핵성대기도협착환자150례，안환자주원순서분위3개조，대조1조、대조2조화연구조。3개조환자균응용항결핵약물、무화흡입、국부주약；대조1조：50례，급여아기도치료；대조2조：50례，급여냉동치료；연구조：50례，칙급여지기관경개입냉동연합아기도치료。3개조총료정6개월。병대3개조림상치료효과진행대비분석。결과3개조환자적경치료후，연구조적완해솔위94．0％，명현우우대조1조적70．0％화대조2조적64．0％，조간차이유통계학의의（ P＜0．05）。동시，연구조환자기관내경급 FEV1／FVC비치야교대조1조、대조2조명현개선，차이유통계학의의（P＜0．05）。결론경지기관경냉동연합아기도진행결핵성대기도협착치료구유교호적림상치료효과，동시안전성고，무엄중병발증，구유교고적림상추엄개치。
Objective To investigate the clinical efficacy of bronchoscopic cryotherapy (CO2 ) combined with argon knife for treating tuberculosis(TB) airway stenosis .Methods 150 cases of TB airway stenosis in our depart‐ment from March 2010 to June 2013 were selected and divided into 3 groups according to the hospitalization order:the control group 1 ,control group 2 and the study group .The 3 groups were treated by anti‐TB drugs ,aerosol inhalation , topical injection of drugs ;the control group 1 (50 cases) was given the argon knife therapy ;the control group 2 (50 cases) was given the cryotherapy ;the study group(50 cases) was treated with bronchoscopic interventional cryother‐apy combined with argon knife .The total course of treatment was 6 months .The clinical effects in 3 groups were per‐formed the comparative analysis .Results The relief rate after treatment in the study group was 94 .0% ,which was significantly superior to 70 .0% and 64 .0% in the control group 1 and 2 ,the differences among them showed the sta‐tistical significance (P<0 .05) .Meanwhile ,the tracheal internal diameter and FEV1/FVC values in the study group were significantly improved compared with the control group 1 and 2 ,the difference had statistical significance(P<0 .05) .Conclusion The bronchoscopic cryotherapy combined with argon knife has better clinical effect for treating tuberculosis airway stenosis ,at the same time has high safety without serious complications and with high clinical promotion value .