CAJ | 학술논문

目的：探讨冠心病患者肺炎衣原体（CPN）、幽门螺杆菌（Hp）、人类巨细胞病毒（HCMV）3种病原微生物的感染状况与3种血清炎症标志物[超敏C‐反应蛋白（hs‐CRP）、白细胞介素‐6（IL‐6）和肿瘤坏死因子‐α（TNF‐α）]水平的相关性。方法选取2012年7月至2013年12月住院的冠心病患者105例作为冠心病组，同时选择同期住院非冠心病患者76例作为对照组。检测两组CPN、Hp、HCMV 3种微生物的IgG抗体，以及血清中hs‐CRP、IL‐6和TNF‐α浓度。结果冠心病组CPN‐IgG、Hp‐IgG和 HCMV‐IgG 单阳性、双阳性和三阳性的阳性率分别为33．3％、52．3％、78．1％、41．9％、13．3％，对照组阳性率则分别为14．5％、35．5％、63．2％、23．7％、2．6％，两组的相应阳性率比较差异有统计学意义（P＜0．05）。CPN‐IgG 、Hp‐IgG和 HCMV‐IgG阳性对患冠心病的危险度比值比分别为3．297、2．278、2．352，差异有统计学意义（ P＜0．05）。随着冠心病的病原体感染负荷增加，3种血清炎症标志物浓度亦增加，每组间差异有统计学意义（P＜0．05）。结论冠心病患者存在CPN、Hp、HCMV 3种病原微生物的混合感染，长期反复慢性混合感染与冠心病关系密切，可诱导炎症标志物之间相互协同共同参与冠心病的发生、发展过程。感染性因素是冠心病的独立危险因素，对冠心病的诊断治疗有积极意义。
목적：탐토관심병환자폐염의원체（CPN）、유문라간균（Hp）、인류거세포병독（HCMV）3충병원미생물적감염상황여3충혈청염증표지물[초민C‐반응단백（hs‐CRP）、백세포개소‐6（IL‐6）화종류배사인자‐α（TNF‐α）]수평적상관성。방법선취2012년7월지2013년12월주원적관심병환자105례작위관심병조，동시선택동기주원비관심병환자76례작위대조조。검측량조CPN、Hp、HCMV 3충미생물적IgG항체，이급혈청중hs‐CRP、IL‐6화TNF‐α농도。결과관심병조CPN‐IgG、Hp‐IgG화 HCMV‐IgG 단양성、쌍양성화삼양성적양성솔분별위33．3％、52．3％、78．1％、41．9％、13．3％，대조조양성솔칙분별위14．5％、35．5％、63．2％、23．7％、2．6％，량조적상응양성솔비교차이유통계학의의（P＜0．05）。CPN‐IgG 、Hp‐IgG화 HCMV‐IgG양성대환관심병적위험도비치비분별위3．297、2．278、2．352，차이유통계학의의（ P＜0．05）。수착관심병적병원체감염부하증가，3충혈청염증표지물농도역증가，매조간차이유통계학의의（P＜0．05）。결론관심병환자존재CPN、Hp、HCMV 3충병원미생물적혼합감염，장기반복만성혼합감염여관심병관계밀절，가유도염증표지물지간상호협동공동삼여관심병적발생、발전과정。감염성인소시관심병적독립위험인소，대관심병적진단치료유적겁의의。
Objective To explore the correlation between the infection status of Chlamydia pneumoniae (CPN) ,Helicobacter pylori(Hp) ,human cytomegalovirus(HCMV) and the levels of serum inflammatory cytokines of high sensitive C‐reactive protein(hs‐CRP) ,interleukin‐6(IL‐6) and tumor necrosis ractor‐α(TNF‐α) in the patients with coronary heart disease(CHD) .Methods 105 inpatients with CHD in our hospital from July 2012 to December 2013 were randomly selected as the CHD group and contemporaneous 76 persons for conducting the healthy examina‐tion were selected as the healthy control group .The serum IgG antibodies of CPN ,Hp and HCMV ;hs‐CRP ,IL‐6 and TNF‐αwere detected .The serum hs‐CRP ,IL‐6 and TNF‐αleves also detected .Results The single ,double and triple positive rates of CPN‐IgG ,Hp‐IgG and HCMV‐IgG in the CHD group were 33 .3% ,52 .3% ,78 .1% ,41 .9% and 13 .3% respectively ;which in the control group were 14 .5% ,35 .5% ,63 .2% ,23 .7% and 2 .6% respectively ,the diferences among them had statistical differences(P<0 .05) .The risk degrees of positive CPN‐IgG ,Hp‐IgG and HC‐MV‐IgG for suffering from CHD were 3 .297 ,2 .278 and 2 .352 ,the difference had statistical significance(P<0 .05) . With the increase of pathogenic infection burden in CHD ,the levels of hs‐CRP ,IL‐6 and TNF‐αwere also increased , the diferences among the groups showed statistical significance(P<0 .05) .Conclusion The mixed infection of CPN , HCMV and Hp exist in the patients with CHD .Their long‐term repeated chronic and mixed infection is closely relat‐ed with CHD ,which could induce the inflammatory markers mutually and synergistically participating in the occur‐rence and development process of CHD .The infectious factor is the independent risk factor and has active significance in the diagnosis and treatment of CHD .