CAJ | 학술논문

目的：探讨缺血性脑卒中发生早期神经功能恶化（END ）的相关因素。方法回顾性分析我院2010‐04—2013‐01收治的132例缺血性脑卒中患者的临床资料，按是否发生早期神经功能恶化分为早期神经功能恶化组和非早期神经功能恶化组，采用单因素方差分析和多因素Logistic回归分析2组患者一般资料和各项指标，总结发生早期神经功能恶化的相关因素。结果132例缺血性脑卒中患者发生早期神经功能恶化35例（26.5％）。经多因素Logistic回归分析发现，NIHSS评分高、糖尿病、颈动脉狭窄≥50％、心房颤动以及高血压是影响缺血性脑卒中发生早期神经功能恶化的重要危险因素（ P＜0.05）。结论 NIHSS评分高、糖尿病、颈动脉狭窄≥50％、心房颤动以及高血压都是影响缺血性脑卒中发生早期神经功能恶化的重要危险因素，对合并以上因素的患者应加强干预治疗，积极改善患者预后。
목적：탐토결혈성뇌졸중발생조기신경공능악화（END ）적상관인소。방법회고성분석아원2010‐04—2013‐01수치적132례결혈성뇌졸중환자적림상자료，안시부발생조기신경공능악화분위조기신경공능악화조화비조기신경공능악화조，채용단인소방차분석화다인소Logistic회귀분석2조환자일반자료화각항지표，총결발생조기신경공능악화적상관인소。결과132례결혈성뇌졸중환자발생조기신경공능악화35례（26.5％）。경다인소Logistic회귀분석발현，NIHSS평분고、당뇨병、경동맥협착≥50％、심방전동이급고혈압시영향결혈성뇌졸중발생조기신경공능악화적중요위험인소（ P＜0.05）。결론 NIHSS평분고、당뇨병、경동맥협착≥50％、심방전동이급고혈압도시영향결혈성뇌졸중발생조기신경공능악화적중요위험인소，대합병이상인소적환자응가강간예치료，적겁개선환자예후。
Objective To analyze the risk factors related to early neurological deterioration in patients with ischemic stroke. Methods A retrospective analysis was made on the patients with ischemic stroke in our hospital from 2010 April to 2013 January, and the patients were divided into END group and non‐END group. Single factor analysis and multiple‐factor Lo‐gistic regression analysis were employed to analyze the general information and clinical indicators, and then the risk factors re‐lated to END were summarized. Results 35 cases of early neural function deterioration occurred in this study of 132 cases of patients with ischemic stroke, the incidence rate was 26.5%. Multiple‐factor Logistic regression analysis indicated that the in‐cidence of END could be affected by atrial fibrillation, hypertension, carotid artery stenosis ≥ 50%, diabetes and NIHSS scores. Conclusion Atrial fibrillation, hypertension, carotid artery stenosis≥50%, diabetes and high NIHSS scores are the risk factors that cause early neurological deterioration in patients with ischemic stroke, intervention treatment should be en‐hanced to improve the prognosis.