CAJ | 학술논문

人体血清中甲胎蛋白( AFP)含量已作为肝癌检测的重要指标，快速而准确地检测血清中的AFP含量对肝癌的早期诊断和预后都有极为重要的作用。传统的酶联免疫法存在分析时间长、前处理繁琐等不利因素。利用免疫技术与电化学检测技术结合起来的电化学免疫传感器，由于具有操作简单、灵敏度高、特异性强及成本低等特点，而得到广泛关注。本文将根据所采用的不同检测方式及修饰材料等方面对近年来电化学免疫传感器检测AFP的研究与应用进行评述，并对其发展趋势进行了展望。
인체혈청중갑태단백( AFP)함량이작위간암검측적중요지표，쾌속이준학지검측혈청중적AFP함량대간암적조기진단화예후도유겁위중요적작용。전통적매련면역법존재분석시간장、전처리번쇄등불리인소。이용면역기술여전화학검측기술결합기래적전화학면역전감기，유우구유조작간단、령민도고、특이성강급성본저등특점，이득도엄범관주。본문장근거소채용적불동검측방식급수식재료등방면대근년래전화학면역전감기검측AFP적연구여응용진행평술，병대기발전추세진행료전망。
The content of alpha-fetoprotein( AFP) in human serum has been used as the important indicator for the diagnosis of liver cancer,so the quick and accurate determination of AFP in serum plays a very important role in the early diagnosis and prognosis of liver cancer. The traditional enzyme-linked immunosorbent assay( ELISA) have the disadvantages of long analysis time,complicated pretreatment. Electrochemical biosensor based on the combination of immunological technique and electrochemical detection tech-nique,have the advantages of simple treatment,high sensitivity,strong specificity and low cost,have received vigorous attention. In This paper,the recent advance of electrochemical biosensor for detection of AFP have been reviewed according to different signal ac-quisition modes and modified materials,and the prospect of electrochemical biosensor for AFP has also been forecasted.