化学研究与应用
化學研究與應用
화학연구여응용
CHEMICAL RESEARCH AND APPLICATION
2015年
1期
107-109
,共3页
亓亮%闻永举%吕美云%郭孟萍
亓亮%聞永舉%呂美雲%郭孟萍
기량%문영거%려미운%곽맹평
Suzuki偶联反应%2-氰基-4′-甲基联苯%环境友好%催化%合成
Suzuki偶聯反應%2-氰基-4′-甲基聯苯%環境友好%催化%閤成
Suzuki우련반응%2-청기-4′-갑기련분%배경우호%최화%합성
Suzuki coupling reaction%2-cyano-4′-methylbiphenyl%environment friendly%catalysis%synthesis
以邻氯苯甲腈和对甲基苯硼酸为原料，绿色溶剂水和PEG400为混合溶剂，经Suzuki偶联反应合成了沙坦联苯(2-氰基-4′-甲基联苯)。目标化合物经1 H NMR、13 C NMR表征。考察了反应温度、反应时间对反应的影响，研究了目标产物的分离纯化，分离产率63%，纯度99．3%( HPLC)。
以鄰氯苯甲腈和對甲基苯硼痠為原料，綠色溶劑水和PEG400為混閤溶劑，經Suzuki偶聯反應閤成瞭沙坦聯苯(2-氰基-4′-甲基聯苯)。目標化閤物經1 H NMR、13 C NMR錶徵。攷察瞭反應溫度、反應時間對反應的影響，研究瞭目標產物的分離純化，分離產率63%，純度99．3%( HPLC)。
이린록분갑정화대갑기분붕산위원료，록색용제수화PEG400위혼합용제，경Suzuki우련반응합성료사탄련분(2-청기-4′-갑기련분)。목표화합물경1 H NMR、13 C NMR표정。고찰료반응온도、반응시간대반응적영향，연구료목표산물적분리순화，분리산솔63%，순도99．3%( HPLC)。
H2O/PEG400 was used as the co-solvent,sartanbiphenyl(2-cyano-4′-methylbiphenyl)was synthesized via Suzuki cross-coupling reaction using 2-chlorobenzonitrile and 4-methylphenylboronic acid as starting material. The target compound was charac-terized by 1 H NMR and 13 C NMR. The effects of temperature and time on the reaction were investigated. The purification of the tar-get compound was studied. The separate yield of 63%and the HPLC purity of 99. 3%were obtained.
