南通大学学报（医学版）
南通大學學報（醫學版）
남통대학학보（의학판）
JOURNAL OF NANTONG UNIVERSITY(MEDICAL SCIENCES)
2015年
1期
42-44,45
,共4页
急性脑梗死%甲状腺激素%糖化血红蛋白%C反应蛋白%内中膜厚度
急性腦梗死%甲狀腺激素%糖化血紅蛋白%C反應蛋白%內中膜厚度
급성뇌경사%갑상선격소%당화혈홍단백%C반응단백%내중막후도
acute cerebral infarction%thyroid hormone%glycocylated hemoglobin Alc%C-reactive protein%intima-media thickness
目的：探讨急性脑梗死患者血清甲状腺激素(thyroid hormone, TH)、糖化血红蛋白(glycocylated hemoglobin Alc, HbAlc)和C反应蛋白(C-reactive protein, CRP)水平的临床价值。方法：对132例急性脑梗死患者和98例正常对照组血清TH、HbAlc和CRP水平进行测定，并进行对比性研究。通过彩超测量了颈动脉内中膜厚度(intima-media thickness, IMT)，并与TH、HbAlc和CRP水平进行了相关性分析。结果：急性脑梗死患者血清三碘甲状腺原氨酸(triiodothyronine, T3)和游离T3(free T3，FT3)水平较正常对照组降低(P＜0.001, P＜0.01)，血清甲状腺素(thyroxine，T4）、游离T4(free T4，FT4)和促甲状腺素(thyroid stimulating hormone，TSH）明显增高(P＜0.05、P＜0.05和P＜0.01)，HbAlc和CRP水平亦明显增高(P＜0.05和P＜0.01)。急性脑梗死患者颈动脉IMT与T3、FT3水平呈负相关，与T4、FT4、TSH、HbAlc和CRP水平呈正相关。结论：急性脑梗死存在TH的保护性应激反应，HbAlc和CRP水平的增高与颈动脉粥样硬化具有一定的相关性。
目的：探討急性腦梗死患者血清甲狀腺激素(thyroid hormone, TH)、糖化血紅蛋白(glycocylated hemoglobin Alc, HbAlc)和C反應蛋白(C-reactive protein, CRP)水平的臨床價值。方法：對132例急性腦梗死患者和98例正常對照組血清TH、HbAlc和CRP水平進行測定，併進行對比性研究。通過綵超測量瞭頸動脈內中膜厚度(intima-media thickness, IMT)，併與TH、HbAlc和CRP水平進行瞭相關性分析。結果：急性腦梗死患者血清三碘甲狀腺原氨痠(triiodothyronine, T3)和遊離T3(free T3，FT3)水平較正常對照組降低(P＜0.001, P＜0.01)，血清甲狀腺素(thyroxine，T4）、遊離T4(free T4，FT4)和促甲狀腺素(thyroid stimulating hormone，TSH）明顯增高(P＜0.05、P＜0.05和P＜0.01)，HbAlc和CRP水平亦明顯增高(P＜0.05和P＜0.01)。急性腦梗死患者頸動脈IMT與T3、FT3水平呈負相關，與T4、FT4、TSH、HbAlc和CRP水平呈正相關。結論：急性腦梗死存在TH的保護性應激反應，HbAlc和CRP水平的增高與頸動脈粥樣硬化具有一定的相關性。
목적：탐토급성뇌경사환자혈청갑상선격소(thyroid hormone, TH)、당화혈홍단백(glycocylated hemoglobin Alc, HbAlc)화C반응단백(C-reactive protein, CRP)수평적림상개치。방법：대132례급성뇌경사환자화98례정상대조조혈청TH、HbAlc화CRP수평진행측정，병진행대비성연구。통과채초측량료경동맥내중막후도(intima-media thickness, IMT)，병여TH、HbAlc화CRP수평진행료상관성분석。결과：급성뇌경사환자혈청삼전갑상선원안산(triiodothyronine, T3)화유리T3(free T3，FT3)수평교정상대조조강저(P＜0.001, P＜0.01)，혈청갑상선소(thyroxine，T4）、유리T4(free T4，FT4)화촉갑상선소(thyroid stimulating hormone，TSH）명현증고(P＜0.05、P＜0.05화P＜0.01)，HbAlc화CRP수평역명현증고(P＜0.05화P＜0.01)。급성뇌경사환자경동맥IMT여T3、FT3수평정부상관，여T4、FT4、TSH、HbAlc화CRP수평정정상관。결론：급성뇌경사존재TH적보호성응격반응，HbAlc화CRP수평적증고여경동맥죽양경화구유일정적상관성。
Objective: To explore the clinical value of serum thyroid hormone(TH), glycocylated hemoglobin Alc(HbAlc) and C-reactive protein(CRP) levels in patients with acute cerebral infarction. Methods: The serum TH, HbA1c and CRP levels were determined in 132 patients with acute cerebral infarction and 98 controls as well as done compared analysis. Ultrasonography was performed to measure the intima-media thickness (IMT) and relative analysis was done with TH, HbAlc and CRP levels. Results: The serum T3 and FT3 levels in patients with acute cerebral infarction were significantly lower than those in controls(P<0.001, P<0.01), the serum T4, FT4 and TSH levels increased significantly(P<0.05, P<0.05 and P<0.01), the serum HbAlc and CRP levels increased significantly also(P<0.05 and P<0.01). The levels of T3 and FT3 and their cross product showed negative correlation with carotid IMT in patients with acute cerebral infarction, but the levels of T4, FT4, TSH, HbAlc and CRP and their cross product showed positive correlation. Conclusion: The TH had protect exiting reaction and HbAlc and CRP increasing was correlated with carotid atherosclerosin in patients with acute cerebral infarction.
