CAJ | 학술논문

目的：观察联合应用奥拉西坦与尼莫地平治疗轻度血管性认知障碍的临床疗效和安全性。方法按照数字表将2011年1月～2014年1月我院轻度血管性认知障碍患者132例随机的分成对照组和观察各66例，对照组应用尼莫地平进行治疗，观察组应用尼莫地平的同时应用奥拉西坦进行联合治疗，治疗周期为6个月，对两组患者治疗后的精神状态量表（MMSE）评分、日常生活活动能力量表（ADL）评分以及副反应的发生情况进行比较。结果对照组患者治疗后MMSE评分为（26.62±1.25）分，观察组患者治疗后MMSE评分为（27.43±1.32）分，两组比较具有统计学的差异（P＜0.05）。对照组患者治疗后ADL评分为（9.79±0.91）分，观察组患者治疗后ADL评分为（7.52±0.83）分，两组比较具有显著地统计学的差异（P＜0.01）。两组患者均无一例副反应发生。结论奥拉西坦与尼莫地平的联合使用能够明显的改善患者的认知能力和日常生活能力，效果优于尼莫地平单独治疗的效果，同时并没有增加副反应的发生，是一种安全、可靠、高效的治疗轻度血管性认知障碍方法。
목적：관찰연합응용오랍서탄여니막지평치료경도혈관성인지장애적림상료효화안전성。방법안조수자표장2011년1월～2014년1월아원경도혈관성인지장애환자132례수궤적분성대조조화관찰각66례，대조조응용니막지평진행치료，관찰조응용니막지평적동시응용오랍서탄진행연합치료，치료주기위6개월，대량조환자치료후적정신상태량표（MMSE）평분、일상생활활동능역량표（ADL）평분이급부반응적발생정황진행비교。결과대조조환자치료후MMSE평분위（26.62±1.25）분，관찰조환자치료후MMSE평분위（27.43±1.32）분，량조비교구유통계학적차이（P＜0.05）。대조조환자치료후ADL평분위（9.79±0.91）분，관찰조환자치료후ADL평분위（7.52±0.83）분，량조비교구유현저지통계학적차이（P＜0.01）。량조환자균무일례부반응발생。결론오랍서탄여니막지평적연합사용능구명현적개선환자적인지능력화일상생활능력，효과우우니막지평단독치료적효과，동시병몰유증가부반응적발생，시일충안전、가고、고효적치료경도혈관성인지장애방법。
Objective To observe the clinical curative effect and security of oxiracetam and nimodipine in the treatment of patients with mild vascular cognitive impairment. Methods According to the digital meter method,132 cases patients were randomly divided into control groups and observation groups, each group has 66 cases.Apply nimodipine for control groups,at the same time,apply oxiracetam and nimodipine for observation groups,To compare the ADL score,the MMSE score and the occurrence of adverse reaction. Results The MMSE score of control group was (26.62±1.25) after treatment,The MMSE score of observation groups was(27.43±1.32)after treatment,the difference between two group was significant(P<0.05);The ADL score of the control group was (9.79±0.91) after treatment, The ADL score of the observation group was (7.52±0.83) after treatment,, the difference between two group was significant(P<0.05).Conclusion Combine oxiracetam and nimodipine Can obviously improve patients cognitive ability and the ability of daily life,it was better than that of using of nimodipine singely. It is a safe, reliable, and efficient method of treatment of mild vascular cognitive impairment.It has the value of clinical application.