CAJ | 학술논문

目的：探讨幽门螺旋杆菌（H.pylori）感染与慢性胃炎胃黏膜病理变化间的关系。方法收集2011年11月—2013年3月天津市人民医院门诊和住院慢性胃炎患者共250例，全部患者行胃镜、病理和14C呼气试验检查，其中慢性萎缩性胃炎（CAG）组153例，非CAG组97例，比较2组的H.pylori阳性率，同时比较不同部位（胃窦、胃窦胃体）CAG患者的H.pylori阳性率。比较不同病理特征下慢性胃炎活动性、炎症程度、萎缩程度、肠化分级的H.pylori阳性率。结果 CAG组的H.pylori阳性率高于非CAG组（70.6%vs 35%，χ2=30.552），CAG组中胃窦胃体均萎缩患者的H.pylori阳性率高于仅胃窦萎缩患者（82.6%vs 65.4%，χ2=4.578），随着慢性胃炎活动性、炎症程度、萎缩程度、肠化分级的加重，其H.pylori阳性率增高（χ2分别为200.643、206.715、73.286、218.432）。结论 H.pylori感染与慢性胃炎、慢性萎缩性胃炎关系密切，尤其与胃窦胃体均萎缩的萎缩性胃炎关系更为密切。
목적：탐토유문라선간균（H.pylori）감염여만성위염위점막병리변화간적관계。방법수집2011년11월—2013년3월천진시인민의원문진화주원만성위염환자공250례，전부환자행위경、병리화14C호기시험검사，기중만성위축성위염（CAG）조153례，비CAG조97례，비교2조적H.pylori양성솔，동시비교불동부위（위두、위두위체）CAG환자적H.pylori양성솔。비교불동병리특정하만성위염활동성、염증정도、위축정도、장화분급적H.pylori양성솔。결과 CAG조적H.pylori양성솔고우비CAG조（70.6%vs 35%，χ2=30.552），CAG조중위두위체균위축환자적H.pylori양성솔고우부위두위축환자（82.6%vs 65.4%，χ2=4.578），수착만성위염활동성、염증정도、위축정도、장화분급적가중，기H.pylori양성솔증고（χ2분별위200.643、206.715、73.286、218.432）。결론 H.pylori감염여만성위염、만성위축성위염관계밀절，우기여위두위체균위축적위축성위염관계경위밀절。
Objective To investigate the correlation between helicobacter pylori (H.pylori) infection with gastric muco?sa pathologic changes in chronic gastritis. Methods A total of 250 patients with chronic gastritis who came to Tianjin Union Medicine Center from November 2011 to March 2013 were collected in this study. Electronic gastroscope examina?tions, pathology and Urea-14C breath tests were performed in patients. There were 153 cases with chronic atrophic gastritis (CAG group), and 97 cases without chronic atrophic gastritis (non-CAG group). The positive rate of H.pylori was compared between two groups. At the same time the positive rate of H.pylori was compared between different parts of CAG patients. The positive rates of H.pylori were compared between different pathologic features of chronic gastritis (active degree, the de?gree of inflammation, atrophy and intestinal classification). Results The positive rate of H.pylori was higher in CAG pa?tients than that of non-CAG patients (70.6%vs 35%,χ2=30.552). The positive rate of H.pylori was higher in antral and cor?pus atrophy of CAG group than that of antral atrophy (82.6%vs 65.4%,χ2=4.578). With the aggravating activity of gastritis, the inflammation, chronic gastritis, atrophy and intestinal classification, the positive rate of H.pylori was increased (χ2=200.643, 206.715, 73.286, 218.432). Conclusion H.pylori infection is related with chronic gastritis, chronic atrophic gas?tritis. And antral and corpus atrophy CAG is closely related with H.pylori infection.