天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2015年
1期
51-53
,共3页
梅志勤%董海彦%冯军花%郭云%刘志权%王春岚
梅誌勤%董海彥%馮軍花%郭雲%劉誌權%王春嵐
매지근%동해언%풍군화%곽운%류지권%왕춘람
苦参%苦参碱%休克,脓毒性%肾%苦参素%内毒素性休克%肾损伤
苦參%苦參堿%休剋,膿毒性%腎%苦參素%內毒素性休剋%腎損傷
고삼%고삼감%휴극,농독성%신%고삼소%내독소성휴극%신손상
sophora flavescens%matrine%shock,septic%kidney%oxymatrine%endotoxic shock%injury of renal func-tion
目的:观察苦参素对内毒素性休克大鼠肾损伤的保护作用。方法将24只雄性Wistar大鼠随机分为正常组(8只)、内毒素性休克组(8只)和苦参素治疗组(8只),内毒素性休克组和苦参素治疗组从股静脉注射脂多糖(LPS,15 mg/kg)建立内毒素性休克模型,造模15 min后,苦参素治疗组自股静脉输注苦参素注射液,观察其对平均动脉压(MAP)影响,实验结束后取材测定血浆中反映肾功能指标的尿素(Urea)、肌酐(Cr)含量,及肾组织匀浆中炎症因子白介素(IL)-6、IL-10、肿瘤坏死因子-α(TNF-α)的含量。结果苦参素治疗可防止内毒素性休克大鼠MAP的进行性下降;内毒素性休克组大鼠血浆Urea、Cr含量显著高于正常组,肾组织内IL-6、IL-10和TNF-α明显上升,苦参素治疗组大鼠血浆Urea、Cr含量显著低于内毒素性休克组,肾组织内IL-6和TNF-α显著下降。结论苦参素可对内毒素性休克后的肾功能提供一定的保护作用,其机制可能与抑制肾内促炎性细胞因子释放有关。
目的:觀察苦參素對內毒素性休剋大鼠腎損傷的保護作用。方法將24隻雄性Wistar大鼠隨機分為正常組(8隻)、內毒素性休剋組(8隻)和苦參素治療組(8隻),內毒素性休剋組和苦參素治療組從股靜脈註射脂多糖(LPS,15 mg/kg)建立內毒素性休剋模型,造模15 min後,苦參素治療組自股靜脈輸註苦參素註射液,觀察其對平均動脈壓(MAP)影響,實驗結束後取材測定血漿中反映腎功能指標的尿素(Urea)、肌酐(Cr)含量,及腎組織勻漿中炎癥因子白介素(IL)-6、IL-10、腫瘤壞死因子-α(TNF-α)的含量。結果苦參素治療可防止內毒素性休剋大鼠MAP的進行性下降;內毒素性休剋組大鼠血漿Urea、Cr含量顯著高于正常組,腎組織內IL-6、IL-10和TNF-α明顯上升,苦參素治療組大鼠血漿Urea、Cr含量顯著低于內毒素性休剋組,腎組織內IL-6和TNF-α顯著下降。結論苦參素可對內毒素性休剋後的腎功能提供一定的保護作用,其機製可能與抑製腎內促炎性細胞因子釋放有關。
목적:관찰고삼소대내독소성휴극대서신손상적보호작용。방법장24지웅성Wistar대서수궤분위정상조(8지)、내독소성휴극조(8지)화고삼소치료조(8지),내독소성휴극조화고삼소치료조종고정맥주사지다당(LPS,15 mg/kg)건립내독소성휴극모형,조모15 min후,고삼소치료조자고정맥수주고삼소주사액,관찰기대평균동맥압(MAP)영향,실험결속후취재측정혈장중반영신공능지표적뇨소(Urea)、기항(Cr)함량,급신조직균장중염증인자백개소(IL)-6、IL-10、종류배사인자-α(TNF-α)적함량。결과고삼소치료가방지내독소성휴극대서MAP적진행성하강;내독소성휴극조대서혈장Urea、Cr함량현저고우정상조,신조직내IL-6、IL-10화TNF-α명현상승,고삼소치료조대서혈장Urea、Cr함량현저저우내독소성휴극조,신조직내IL-6화TNF-α현저하강。결론고삼소가대내독소성휴극후적신공능제공일정적보호작용,기궤제가능여억제신내촉염성세포인자석방유관。
Objective To evaluate the protective effects of oxymatrine injection on rats with endotoxic shock. Methods Wistar rat model of endotoxic shock was produced in this study. Twenty-four Wistar rats were randomly divided into normal control group (n=8), endotoxic shock group (n=8) and oxymatrine injection treatment group (n=8). Fifteen min?utes after the infusion of LPS (15 mg/kg) from femoral vein, oxymatrine was injected from femoral vein in treatment group, then we observed the mean arterial pressure (MAP) for six hours. At the end of experiment blood samples were harvested for measurement of urea and creatinine (Cr), which reflect renal function. Also contents of IL-6, IL-10, TNF-αin the renal ho?mogenate were detected. Results Oxymatrine can prevent progressive decrease of MAP in endotoxin shock treatment group. The contents of plasma urea and Cr were significantly higher in endotoxin shock group than those of control group. The contents of IL-6, IL-10 and TNF-αin renal homogenate increased obviously, but after the injection of oxymatrine, the contents of urea and Cr significantly decreased in treatment group, also IL-6 and TNF-α were significantly declined. Conclusion Oxymatrine provides protection at renal function after endotoxin shock, and its mechanism may be related to inhibit the releasing of inflammatory cytokines in kidney.