CAJ | 학술논문

OCT4基因是POU转录因子家族中的一员，它能与含八聚体基序（ATGCAAAT）的DNA结合。OCT4是一个关键的转录因子，在未分化胚胎干细胞中参与维持多能性和自我更新性，在许多种癌症包括肺癌、生殖细胞肿瘤、乳腺癌、宫颈癌、前列腺癌、胃癌、肝癌和卵巢癌中过表达。MicroRNAs（miRNAs）是一种小的非编码RNA，通过和靶基因mRNA碱基配对来调控mRNA表达，降解mRNA或阻碍蛋白合成。一些miRNAs被证实在癌细胞中调控干细胞因子如OCT4、NANOG、SOX2和KLF4，进而调控癌细胞的增殖、凋亡、分化、抗药性和免疫性。
OCT4기인시POU전록인자가족중적일원，타능여함팔취체기서（ATGCAAAT）적DNA결합。OCT4시일개관건적전록인자，재미분화배태간세포중삼여유지다능성화자아경신성，재허다충암증포괄폐암、생식세포종류、유선암、궁경암、전렬선암、위암、간암화란소암중과표체。MicroRNAs（miRNAs）시일충소적비편마RNA，통과화파기인mRNA감기배대래조공mRNA표체，강해mRNA혹조애단백합성。일사miRNAs피증실재암세포중조공간세포인자여OCT4、NANOG、SOX2화KLF4，진이조공암세포적증식、조망、분화、항약성화면역성。
Octamer-binding transcription factor 4 (OCT4) belongs to the POU-homeodomain family of tran-scription factors and binds to an octamer motif, ATGCAAAT. OCT4 is the key transcription factor that is involved in the maintenance of pluripotency and self-renewal in undiferentiated embryonic stem (ES) cells. OCT4 has been reported to be overexpressed in various cancers including lung, germ cell tumors, breast, cervix, prostate, gastric, liver, and ovarian cancer. Mi-croRNAs (miRNAs), small non-coding RNAs, modulate mRNA expression through base pairing between seed sequences in miRNA and complementary sequences of the target mRNA, thereby destabilizing mRNA and/or inhibiting protein synthesis. Several miRNAs have been demonstrated to regulate stemness factors such as OCT4, NANOG, SOX2 and KLF4 in cancer cells, thereby modulating the proliferation, apoptosis, diferentiation, drug resistance and immunity of cancer cells.