CAJ | 학술논문

建立了离子色谱–抑制电导法检测伊班膦酸钠中亚磷酸根和磷酸根离子的方法。实验采用SH–AC–1型离子交换色谱柱，3.6 mmol／L碳酸钠–4.5 mmol／L碳酸氢钠为淋洗液，流量为1.5 mL／min，进样体积为20μL。在此条件下，可同时分离亚磷酸和磷酸根离子，且色谱峰型对称。所测H2PO3–，H2PO4–离子的检出限(S／N=3)分别为0.027，0.053 mg／L。应用该方法测定H2PO3–，H2PO4–离子，加标回收率分别为95.7%～108.1%，99.8%～107.7%，测定结果的相对标准偏差分别为2.5%，5.6%(n=6)。该方法简单，测定结果准确、可靠，可以用于实际生产中监测伊班膦酸钠的质量。
건립료리자색보–억제전도법검측이반련산납중아린산근화린산근리자적방법。실험채용SH–AC–1형리자교환색보주，3.6 mmol／L탄산납–4.5 mmol／L탄산경납위림세액，류량위1.5 mL／min，진양체적위20μL。재차조건하，가동시분리아린산화린산근리자，차색보봉형대칭。소측H2PO3–，H2PO4–리자적검출한(S／N=3)분별위0.027，0.053 mg／L。응용해방법측정H2PO3–，H2PO4–리자，가표회수솔분별위95.7%～108.1%，99.8%～107.7%，측정결과적상대표준편차분별위2.5%，5.6%(n=6)。해방법간단，측정결과준학、가고，가이용우실제생산중감측이반련산납적질량。
The method for determination of phosphate and phosphorous in ibandronate sodium by ion chromatography–suppressed conductivity detection was established. SH–AC–1 ion exchange column was used, 3.6 mmol/L sodium carbonate–4.5 mmol/L sodium bicarbonate was used as the eluent with theflow rate of 1.5 mL/min, and sample volume was 20μL. In these conditions,the separation of H2PO3–,H2PO4– was carried out with symmetric peak. The detection limit(S/N=3) of H2PO3– and H2PO4– was 0.027,0.053 mg/L, respectively. The recoveries of H2PO3–,H2PO4– were 95.7%–108.1%,99.8%–107.7%,respectively,and the relative standard deviation of determination results was 2.5%, 5.6%(n=6),respectively. This method is simple,accurate,reliable,and better practical applicability. It can be monitored quality of ibandronate sodium during product manufacturing.