CAJ | 학술논문

目的：观察肺癌骨转移患者放疗前后血清Ⅰ型胶原羧基端肽β特殊序列（β-CTX）和Ⅰ型前胶原N-端前肽（ PINP）的变化，并分析其与放疗疗效的关系。方法对28例肺癌骨转移患者均给予6 MV X线放射治疗，每周5次，3 Gy／F，总剂量30 Gy。放疗后评价疗效，放疗前后电化学发光法检测血清β-CTX和PINP，比较放疗前后血清β-CTX和PINP变化及其与放疗疗效的关系。结果肺癌骨转移患者放疗后止痛效果为完全缓解9例、部分缓解10例、无缓解9例、有效率为67．86％，血清β-CTX和PINP水平均较放疗前明显下降（P均＜0．05）。放疗有效者放疗后血清β-CTX、PINP水平较放疗前明显下降（P均＜0．05），放疗无效者放疗后血清PINP水平较放疗前有所下降（P＜0．05），β-CTX略有下降，但差异无统计学意义（P＞0．05）。结论肺癌骨转移患者放疗后血清β-CTX和PINP较放疗前降低，二者可作为肺癌骨转移患者放疗疗效评价的辅助指标。
목적：관찰폐암골전이환자방료전후혈청Ⅰ형효원최기단태β특수서렬（β-CTX）화Ⅰ형전효원N-단전태（ PINP）적변화，병분석기여방료료효적관계。방법대28례폐암골전이환자균급여6 MV X선방사치료，매주5차，3 Gy／F，총제량30 Gy。방료후평개료효，방료전후전화학발광법검측혈청β-CTX화PINP，비교방료전후혈청β-CTX화PINP변화급기여방료료효적관계。결과폐암골전이환자방료후지통효과위완전완해9례、부분완해10례、무완해9례、유효솔위67．86％，혈청β-CTX화PINP수평균교방료전명현하강（P균＜0．05）。방료유효자방료후혈청β-CTX、PINP수평교방료전명현하강（P균＜0．05），방료무효자방료후혈청PINP수평교방료전유소하강（P＜0．05），β-CTX략유하강，단차이무통계학의의（P＞0．05）。결론폐암골전이환자방료후혈청β-CTX화PINP교방료전강저，이자가작위폐암골전이환자방료료효평개적보조지표。
Objective To investigate the clinical significance of βisomer of C-terminal telopeptide (β-CTX) and a-mino-terminal propeptide of type I collagen ( PINP) in lung cancer patients with bone metastasis before and after radiothera-py.Methods A total of 28 lung cancer patients with bone metastasis were enrolled in this study .Serumβ-CTX and PINP were measured before and after radiotherapy .The relationship between the level of serum β-CTX, PINP before and after ra-diotherapy and the response to radiotherapy were analyzed .Results 9 cases had complete remission of pain after radiother-apy, 10 cases partial remission, 9 cases no remission, the effective rate was 67.86%.Compared with pre-radiotherapy, the levels of β-CTX and PINP deceased after radiotherapy (both P<0.05).For radiotherapy responding group , the levels ofβ-CTX and PINP decreased after radiotherapy (both P<0.05).For radiotherapy non-responding group, the level of PINP decreased (P<0.05), while β-CTX slightly decreased (P>0.05).Conclusions The levels of β-CTX and PINP in serum of lung cancer patients with bone metastasis measurement after radiotherapy decreased compare with before radio -therapy, which might be as valuable index to monitor radiotherapy response .